Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Res Health Sci. 2020 Jul 30;20(3):e00486. doi: 10.34172/jrhs.2020.18.
Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD.
A case-control study.
In this age-and sex-matched case-control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168-item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC.
Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P<0.050), and lower physical activity and DTAC scores (P<0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91).
A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results.
膳食总抗氧化能力 (DTAC) 已被提议作为评估抗氧化剂摄入量的工具。本研究旨在评估膳食总抗氧化能力 (TAC) 与非酒精性脂肪性肝病 (NAFLD) 发生几率之间是否存在关系。
一项 2019 年进行的病例对照研究。
在这项年龄和性别匹配的病例对照研究中，从医院诊所招募了 NAFLD 患者和健康对照者。所有参与者都完成了一份经过验证的 168 项食物频率问卷，其结果随后被用来生成膳食 TAC。使用氧自由基吸收能力值来计算膳食 TAC。
共纳入 225 例 NAFLD 患者和 450 例健康对照者。与对照组相比，NAFLD 患者的平均体重、BMI、能量更高（P<0.050），身体活动和 DTAC 评分更低（P<0.050）。在调整后的模型中，膳食 TAC 最高四分位的参与者患 NAFLD 的风险较低（比值比 0.78，95%CI：0.67，0.91）。
高 DTAC 与降低 NAFLD 风险相关。提示摄入具有高抗氧化能力的饮食对预防 NAFLD 具有重要意义。需要进行更多设计合理的随机对照试验的逐项研究，以更深入地了解这些结果。
