Salavatizadeh Marieh, Soltanieh Samira, Poustchi Hossein, Yari Zahra, Shabanpur Maryam, Mansour Asieh, Khamseh Mohammad E, Alaei-Shahmiri Fariba, Hekmatdoost Azita
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Front Nutr. 2022 Nov 3;9:1037851. doi: 10.3389/fnut.2022.1037851. eCollection 2022.
This study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM).
We recruited two hundred people with T2DM, and evaluated their liver steatosis using Fibroscan. Dietary intakes of participants were assessed using a validated food frequency questionnaire. DTAC was computed ferric reducing antioxidant power (FRAP).
In the crude model, no statistically significant association was found between DTAC and the odds of NAFLD in people with diabetes. However, after adjustment for potential confounders including age, gender, diabetes duration, smoking status, physical activity, BMI, waist circumference, and energy, the most reduced adjusted OR was indicated for the third tertile the first one (OR: 0.28, 95% CI: 0.09-0.81, = 0.02), meaning that diabetic patients in the third tertile of DTAC had 72% decreased risk of NAFLD in comparison to those in the first one. The relationship was remained significant after additional adjustment for HOMA-IR, HbA1c, serum Triglyceride (TG), and low-density lipoprotein-cholesterol (LDL) levels (OR: 0.29, 95% CI: 0.09-0.93, = 0.03). Importantly, a dose-response pattern was demonstrated for DTAC and risk of NAFLD ( = 0.04).
Higher DTAC was related with a decreased risk of NAFLD in individuals with diabetes.
本研究旨在评估2型糖尿病（T2DM）患者的膳食总抗氧化能力（DTAC）与非酒精性脂肪性肝病（NAFLD）发生几率之间的可能关联。
我们招募了200名T2DM患者，使用Fibroscan评估他们的肝脏脂肪变性情况。通过一份经过验证的食物频率问卷评估参与者的膳食摄入量。DTAC通过铁还原抗氧化能力（FRAP）计算得出。
在粗模型中，未发现DTAC与糖尿病患者NAFLD发生几率之间存在统计学显著关联。然而，在对包括年龄、性别、糖尿病病程、吸烟状况、身体活动、BMI、腰围和能量等潜在混杂因素进行调整后，第三三分位数与第一三分位数相比，调整后的OR值降低最为明显（OR：0.28，95%CI：0.09 - 0.81，P = 0.02），这意味着DTAC处于第三三分位数的糖尿病患者与处于第一三分位数的患者相比，患NAFLD的风险降低了72%。在进一步调整HOMA-IR、糖化血红蛋白（HbA1c）、血清甘油三酯（TG）和低密度脂蛋白胆固醇（LDL）水平后，这种关系仍然显著（OR：0.29，95%CI：0.09 - 0.93，P = 0.03）。重要的是，DTAC与NAFLD风险之间呈现出剂量反应模式（P = 0.04）。
较高的DTAC与糖尿病个体患NAFLD的风险降低有关。
