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解释金属有机骨架-纳米酶纳米/微马达在癌症靶向治疗中的化学线索：基准和挑战。

Explaining chemical clues of metal organic framework-nanozyme nano-/micro-motors in targeted treatment of cancers: benchmarks and challenges.

机构信息

Laboratory Experimental Oncology, Department of Pathology, Erasmus MC, 3015GD, Rotterdam, The Netherlands.

Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

出版信息

J Nanobiotechnology. 2022 Mar 24;20(1):153. doi: 10.1186/s12951-022-01375-z.

DOI:10.1186/s12951-022-01375-z
PMID:35331244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8943504/
Abstract

Nowadays, nano-/micro-motors are considered as powerful tools in different areas ranging from cleaning all types of contaminants, to development of Targeted drug delivery systems and diagnostic activities. Therefore, the development and application of nano-/micro-motors based on metal-organic frameworks with nanozyme activity (abbreviated as: MOF-NZs) in biomedical activities have received much interest recently. Therefore, after investigating the catalytic properties and applications of MOF-NZs in the treatment of cancer, this study intends to point out their key role in the production of biocompatible nano-/micro-motors. Since reducing the toxicity of MOF-NZ nano-/micro-motors can pave the way for medical activities, this article examines the methods of making biocompatible nanomotors to address the benefits and drawbacks of the required propellants. In the following, an analysis of the amplified directional motion of MOF-NZ nano-/micro-motors under physiological conditions is presented, which can improve the motor behaviors in the propulsion function, conductivity, targeting, drug release, and possible elimination. Meanwhile, by explaining the use of MOF-NZ nano-/micro-motors in the treatment of cancer through the possible synergy of nanomotors with different therapies, it was revealed that MOF-NZ nano-/micro-motors can be effective in the treatment of cancer. Ultimately, by analyzing the potential challenges of MOF-NZ nano-/micro-motors in the treatment of cancers, we hope to encourage researchers to develop MOF-NZs-based nanomotors, in addition to opening up new ideas to address ongoing problems.

摘要

如今，纳米/微马达被认为是从清洁各种污染物到开发靶向药物输送系统和诊断活动等不同领域的有力工具。因此，基于具有纳米酶活性的金属有机骨架（简称：MOF-NZ）的纳米/微马达在生物医学领域的开发和应用最近受到了广泛关注。因此，在研究了 MOF-NZ 在癌症治疗中的催化特性和应用后，本研究旨在指出它们在生物相容性纳米/微马达生产中的关键作用。由于降低 MOF-NZ 纳米/微马达的毒性可以为医学活动铺平道路，因此本文研究了制造生物相容性纳米马达的方法，以解决所需推进剂的优缺点。在接下来的内容中，分析了 MOF-NZ 纳米/微马达在生理条件下放大的定向运动，这可以改善推进功能、导电性、靶向性、药物释放和可能消除方面的马达行为。同时，通过解释 MOF-NZ 纳米/微马达在癌症治疗中的应用，即纳米马达与不同疗法的可能协同作用，揭示了 MOF-NZ 纳米/微马达在癌症治疗中的有效性。最终，通过分析 MOF-NZ 纳米/微马达在癌症治疗中面临的潜在挑战，我们希望鼓励研究人员开发基于 MOF-NZ 的纳米马达，除了为解决当前问题提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7837/8944094/89225e571cb5/12951_2022_1375_Fig5_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7837/8944094/89225e571cb5/12951_2022_1375_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7837/8944094/0a3ce6c4af20/12951_2022_1375_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7837/8944094/a61bcdab2e5b/12951_2022_1375_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7837/8944094/9ce65c1b2436/12951_2022_1375_Fig3_HTML.jpg
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