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一位 81 岁老年患者,主因咳嗽、呼吸困难就诊。

A case of an 81-year-old with cough and dyspnea.

机构信息

Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

出版信息

Adv Respir Med. 2020;88(5):454-457. doi: 10.5603/ARM.a2020.0158.

Abstract

It is uncommon to diagnose usual interstitial pneumonitis as a unilateral presentation. We present a case of an 81-year-old current smoker who presented with exertional dyspnea and dry cough. The patient had right sided UIP pattern in the CT chest along with hiatus hernia. The etiology for the unilateral lung involvement was postulated to be due to the hiatus hernia leading to gastro-esophageal reflux disease (GERD) which caused micro aspirations leading to lung injury and fibroblast activation. Whether this can be prevented by anti-reflux medications needs further research. Our patient was managed with pirfenidone, metered dose inhalers containing tiotropium and proton-pump inhibitors Thus, a high index of suspicion for underlying gastro-esophageal reflux must be kept in such patients to arrive at an early diagnosis and start treatment.

摘要

诊断常见间质性肺炎为单侧表现并不常见。我们报告了一例 81 岁的现吸烟患者,其表现为劳力性呼吸困难和干咳。该患者胸部 CT 显示右侧 UIP 模式,同时伴有食管裂孔疝。单侧肺受累的病因被推测是由于食管裂孔疝导致胃食管反流病(GERD),从而导致微吸入导致肺损伤和成纤维细胞激活。通过抗反流药物是否可以预防这种情况需要进一步研究。我们的患者接受了吡非尼酮、噻托溴铵定量吸入器和质子泵抑制剂治疗。因此,对于此类患者,必须保持对潜在胃食管反流的高度怀疑,以便及早诊断和开始治疗。

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