Nucleic Acids Res. 2021 Jan 8;49(D1):D18-D28. doi: 10.1093/nar/gkaa1022.
The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a suite of database resources to support worldwide research activities in both academia and industry. With the explosive growth of multi-omics data, CNCB-NGDC is continually expanding, updating and enriching its core database resources through big data deposition, integration and translation. In the past year, considerable efforts have been devoted to 2019nCoVR, a newly established resource providing a global landscape of SARS-CoV-2 genomic sequences, variants, and haplotypes, as well as Aging Atlas, BrainBase, GTDB (Glycosyltransferases Database), LncExpDB, and TransCirc (Translation potential for circular RNAs). Meanwhile, a series of resources have been updated and improved, including BioProject, BioSample, GWH (Genome Warehouse), GVM (Genome Variation Map), GEN (Gene Expression Nebulas) as well as several biodiversity and plant resources. Particularly, BIG Search, a scalable, one-stop, cross-database search engine, has been significantly updated by providing easy access to a large number of internal and external biological resources from CNCB-NGDC, our partners, EBI and NCBI. All of these resources along with their services are publicly accessible at https://bigd.big.ac.cn.
国家基因组科学数据中心（NGDC）是中国国家生物信息中心（CNCB）的一部分，提供了一系列数据库资源，以支持学术界和工业界的全球研究活动。随着多组学数据的爆炸式增长，CNCB-NGDC 通过大数据的存储、整合和转化，不断扩展、更新和丰富其核心数据库资源。在过去的一年中，CNCB-NGDC 投入了相当大的精力用于建立新资源 2019nCoVR，该资源提供了全球范围内 SARS-CoV-2 基因组序列、变体和单倍型的全景图，以及 Aging Atlas、BrainBase、GTDB（糖基转移酶数据库）、LncExpDB 和 TransCirc（环状 RNA 的翻译潜力）。同时，还对一系列资源进行了更新和改进，包括 BioProject、BioSample、GWH（基因组仓库）、GVM（基因组变异图谱）、GEN（基因表达星云）以及一些生物多样性和植物资源。特别是，BIG Search 作为一个可扩展的一站式跨数据库搜索引擎，通过提供方便的途径访问来自 CNCB-NGDC、我们的合作伙伴 EBI 和 NCBI 的大量内部和外部生物资源，得到了显著的更新。所有这些资源及其服务都可以在 https://bigd.big.ac.cn 上公开访问。
