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通过干扰基础转录机制，HBZ RNA 对 HTLV-1 表达的表观遗传沉默。

Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery.

机构信息

Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Sart-Tilman, Liège, Belgium.

Molecular Biology, Teaching and Research Centre (TERRA), Gembloux, Belgium; and.

出版信息

Blood Adv. 2020 Nov 10;4(21):5574-5579. doi: 10.1182/bloodadvances.2020001675.

DOI:10.1182/bloodadvances.2020001675
PMID:33170933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7656924/
Abstract

By disrupting basal transcription machinery, HBZ RNA inhibits sense transcription of human T-cell leukemia virus type 1. Repression of genomic expression may allow entry into proviral latency and escape from immune response.

摘要

通过破坏基础转录机制，HBZ RNA 抑制了人类 T 细胞白血病病毒 1 的有意义转录。基因组表达的抑制可能允许进入前病毒潜伏期并逃避免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8a1/7656924/5acf6a249d18/advancesADV2020001675absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8a1/7656924/5acf6a249d18/advancesADV2020001675absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8a1/7656924/5acf6a249d18/advancesADV2020001675absf1.jpg

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