通过干扰基础转录机制，HBZ RNA 对 HTLV-1 表达的表观遗传沉默。
Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery.
机构信息
Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Sart-Tilman, Liège, Belgium.
Molecular Biology, Teaching and Research Centre (TERRA), Gembloux, Belgium; and.
出版信息
Blood Adv. 2020 Nov 10;4(21):5574-5579. doi: 10.1182/bloodadvances.2020001675.
Abstract
By disrupting basal transcription machinery, HBZ RNA inhibits sense transcription of human T-cell leukemia virus type 1. Repression of genomic expression may allow entry into proviral latency and escape from immune response.
摘要
通过破坏基础转录机制，HBZ RNA 抑制了人类 T 细胞白血病病毒 1 的有意义转录。基因组表达的抑制可能允许进入前病毒潜伏期并逃避免疫反应。
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