CERVO Brain Research Center, Quebec City, QC, Canada.
Université Laval, Quebec City, QC, Canada.
Autophagy. 2021 Mar;17(3):828-829. doi: 10.1080/15548627.2020.1848120. Epub 2020 Nov 20.
Cell migration is a highly dynamic and energy-intensive process that ensures the correct targeting of cells during embryonic and postnatal development. In recent work, we highlighted the importance of macroautophagy/autophagy in regulating the dynamics of cell migration under baseline conditions and in response to a diverse set of molecular factors. Genetic suppression of autophagy-related genes induced longer stationary phases in migrating cells and cell stalling at the beginning of the migratory stream. We also showed that autophagy is required for recycling of the focal adhesion molecule PXN (paxillin), and is induced by energy levels of cells via AMPK activation. This recent study revealed the importance of autophagy in the maintenance of cell migration, and showed that the dynamic interplay between autophagy and energy levels is required to sustain neuronal migration and to cope with diverse micro-environmental factors.
细胞迁移是一个高度动态和能量密集的过程，它确保了细胞在胚胎和出生后发育过程中的正确靶向。在最近的研究中，我们强调了巨自噬/自噬在调节细胞迁移的动力学方面的重要性，无论是在基线条件下还是在应对多种分子因素时。自噬相关基因的遗传抑制导致迁移细胞的静止期延长，并在迁移流的开始时使细胞停滞。我们还表明，自噬是回收粘着斑分子 PXN（桩蛋白）所必需的，并且通过 AMPK 激活来响应细胞的能量水平。这项最近的研究揭示了自噬在维持细胞迁移中的重要性，并表明自噬和能量水平之间的动态相互作用是维持神经元迁移和应对不同微环境因素所必需的。
