Kisil O V, Efimenko T A, Gabrielyan N I, Efremenkova O V
Gause Institute of New Antibiotics, Moscow, 119021 Russia.
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Healthcare of the Russian Federation, Moscow, 1123182 Russia.
Acta Naturae. 2020 Jul-Sep;12(3):34-45. doi: 10.32607/actanaturae.10955.
The spread of antibiotic resistance among pathogens represents a threat to human health around the world. In 2017, the World Health Organization published a list of 12 top-priority antibiotic-resistant pathogenic bacteria for which new effective antibiotics or new ways of treating the infections caused by them are needed. This review focuses on , one of these top-priority pathogens. The pathogenic bacterium is one of the most frequently encountered infectious agents in the world; its clinically significant features include resistance to UV light, drying, disinfectants, and antibiotics. This review looks at the various attempts that have been made to tackle the problem of drug resistance relating to variants without the use of antibiotics. The potential of bacteriophages and antimicrobial peptides in the treatment of infections caused by in both planktonic and biofilm form is assessed. Such topics as research into the development of vaccines based on the outer membrane proteins of and the use of silver nanoparticles, as well as photodynamic and chelate therapy, are also covered.
病原体中抗生素耐药性的传播对全球人类健康构成威胁。2017年，世界卫生组织公布了一份12种最优先的抗生素耐药病原菌名单，针对这些病原菌需要新的有效抗生素或治疗由它们引起的感染的新方法。本综述聚焦于这些最优先病原菌之一。这种病原菌是世界上最常见的感染源之一；其临床上的显著特征包括对紫外线、干燥、消毒剂和抗生素具有抗性。本综述探讨了在不使用抗生素的情况下应对与该病原菌变种相关的耐药性问题所做的各种尝试。评估了噬菌体和抗菌肽在治疗浮游形式和生物膜形式的该病原菌引起的感染方面的潜力。还涵盖了基于该病原菌外膜蛋白的疫苗研发、银纳米颗粒的使用以及光动力和螯合疗法等研究课题。
