Ningbo Cixi Institute of BioMedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P.R. China.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Nanoscale. 2023 Mar 2;15(9):4261-4276. doi: 10.1039/d2nr06857e.
Zinc (Zn), extolled as "the flower of life" in modern medicine, has been extensively highlighted with its physiological functions to maintain growth, development, and metabolism homeostasis. Driven by the substantial advancement of nanotechnology and oncology, Zn-involved nanomedicines integrating the intrinsic bioactivity of Zn species and the physiochemical attributes of Zn-composed nanosystems have blazed a highly efficient and relatively biosafe antineoplastic path. In this review, we aim to highlight and discuss the recent representative modalities of emerging Zn-involved oncology nanomedicine, mainly emphasizing the rational design, biological effect and biosafety, and therapeutic strategies. In addition, we provide the underlying critical obstacles and future perspectives of Zn-involved oncology nanomedicines, primarily focusing on the chances and challenges of clinical translation. Furthermore, we hope the review can give rise to opportunities within oncology nanomedicine and other biomedical fields, promoting the prosperity and progress of the "Zincic Age".
锌（Zn）在现代医学中被誉为“生命之花”，其维持生长、发育和代谢稳态的生理功能已得到广泛强调。受纳米技术和肿瘤学的巨大进步的推动，整合了 Zn 物种固有生物活性和 Zn 组成的纳米系统物理化学特性的 Zn 相关纳米药物为高效且相对生物安全的抗肿瘤开辟了一条新途径。在这篇综述中，我们旨在强调和讨论最近出现的 Zn 相关肿瘤纳米医学的代表性模式，主要强调合理设计、生物学效应和生物安全性以及治疗策略。此外，我们还提供了 Zn 相关肿瘤纳米医学的潜在关键障碍和未来展望，主要集中在临床转化的机会和挑战上。此外，我们希望这篇综述能为肿瘤纳米医学和其他生物医学领域带来新的机遇，促进“锌时代”的繁荣和进步。
