Hu Hui, Yu Luodan, Qian Xiaoqin, Chen Yu, Chen Baoding, Li Yuehua
Medmaterial Research Center Jiangsu University Affiliated People's Hospital Zhenjiang 212002 P. R. China.
Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 P. R. China.
Adv Sci (Weinh). 2020 Dec 3;8(1):2000494. doi: 10.1002/advs.202000494. eCollection 2020 Jan.
The advances of nanobiotechnology and nanomedicine enable the triggering of in situ chemical reactions in disease microenvironment for achieving disease-specific nanotherapeutics with both intriguing therapeutic efficacy and mitigated side effects. Metal peroxide based nanoparticles, as one of the important but generally ignored categories of metal-involved nanosystems, can function as the solid precursors to produce oxygen (O) and hydrogen peroxide (HO) through simple chemical reactions, both of which are the important chemical species for enhancing the therapeutic outcome of versatile modalities, accompanied with the unique bioactivity of metal ion based components. This progress report summarizes and discusses the most representative paradigms of metal peroxides in chemoreactive nanomedicine, including copper peroxide (CuO), calcium peroxide (CaO), magnesium peroxide (MgO), zinc peroxide (ZnO), barium peroxide (BaO), and titanium peroxide (TiO) nanosystems. Their reactions and corresponding products have been broadly explored in versatile disease treatments, including catalytic nanotherapeutics, photodynamic therapy, radiation therapy, antibacterial infection, tissue regeneration, and some synergistically therapeutic applications. This progress report particularly focuses on the underlying reaction mechanisms on enhancing the therapeutic efficacy of these modalities, accompanied with the discussion on their biological effects and biosafety. The existing gap between fundamental research and clinical translation of these metal peroxide based nanotherapeutic technologies is finally discussed in depth.
纳米生物技术和纳米医学的进展使得在疾病微环境中引发原位化学反应成为可能，从而实现具有诱人治疗效果和减轻副作用的疾病特异性纳米疗法。基于金属过氧化物的纳米颗粒作为金属参与的纳米系统中一类重要但普遍被忽视的类别，可作为固体前体，通过简单化学反应产生氧气（O）和过氧化氢（HO），这两种物质都是增强多种治疗方式治疗效果的重要化学物质，同时还具有基于金属离子成分的独特生物活性。本进展报告总结并讨论了化学活性纳米医学中金属过氧化物最具代表性的范例，包括过氧化铜（CuO）、过氧化钙（CaO）、过氧化镁（MgO）、过氧化锌（ZnO）、过氧化钡（BaO）和过氧化钛（TiO）纳米系统。它们的反应及相应产物已在多种疾病治疗中得到广泛探索，包括催化纳米疗法、光动力疗法、放射疗法、抗菌感染、组织再生以及一些协同治疗应用。本进展报告特别关注增强这些治疗方式疗效的潜在反应机制，并讨论它们的生物学效应和生物安全性。最后深入讨论了这些基于金属过氧化物的纳米治疗技术在基础研究和临床转化之间存在的差距。
