Brzeszczyńska Joanna, Brzeszczyński Filip, Hamilton David F, McGregor Robin, Simpson A Hamish R W
School of Clinical Sciences, University of Edinburgh, Edinburgh, UK.
Department of Molecular Biophysics, University of Lodz, Lodz, Poland.
Bone Joint Res. 2020 Nov;9(11):798-807. doi: 10.1302/2046-3758.911.BJR-2020-0178.R1.
MicroRNAs (miRNAs) are a class of small non-coding RNAs that have emerged as potential predictive, prognostic, and therapeutic biomarkers, relevant to many pathophysiological conditions including limb immobilization, osteoarthritis, sarcopenia, and cachexia. Impaired musculoskeletal homeostasis leads to distinct muscle atrophies. Understanding miRNA involvement in the molecular mechanisms underpinning conditions such as muscle wasting may be critical to developing new strategies to improve patient management. MicroRNAs are powerful post-transcriptional regulators of gene expression in muscle and, importantly, are also detectable in the circulation. MicroRNAs are established modulators of muscle satellite stem cell activation, proliferation, and differentiation, however, there have been limited human studies that investigate miRNAs in muscle wasting. This narrative review summarizes the current knowledge as to the role of miRNAs in the skeletal muscle differentiation and atrophy, synthesizing the findings of published data. Cite this article: 2020;9(11):798-807.
微小RNA（miRNA）是一类小的非编码RNA，已成为潜在的预测、预后和治疗生物标志物，与包括肢体固定、骨关节炎、肌肉减少症和恶病质在内的许多病理生理状况相关。肌肉骨骼稳态受损会导致不同类型的肌肉萎缩。了解miRNA在诸如肌肉萎缩等状况的分子机制中的作用，对于制定改善患者管理的新策略可能至关重要。微小RNA是肌肉中基因表达的强大转录后调节因子，重要的是，它们在循环中也可检测到。微小RNA是肌肉卫星干细胞激活、增殖和分化的既定调节因子，然而，研究肌肉萎缩中miRNA的人体研究有限。本叙述性综述总结了目前关于miRNA在骨骼肌分化和萎缩中的作用的知识，综合了已发表数据的研究结果。引用本文：2020；9（11）：798 - 807。
