Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
Mol Plant Pathol. 2021 Jan;22(1):145-150. doi: 10.1111/mpp.13012. Epub 2020 Nov 11.
Plant immune signalling activated by the perception of pathogen-associated molecular patterns (PAMPs) or effector proteins is mediated by pattern-recognition receptors (PRRs) and nucleotide-binding and leucine-rich repeat domain-containing receptors (NLRs), which often share cellular components and downstream responses. Many PRRs are leucine-rich repeat receptor-like kinases (LRR-RLKs), which mostly perceive proteinaceous PAMPs. The suppressor of the G2 allele of skp1 (SGT1) is a core immune regulator required for the activation of NLR-mediated immunity. In this work, we examined the requirement of SGT1 for immune responses mediated by several LRR-RLKs in both Nicotiana benthamiana and Arabidopsis. Using complementary genetic approaches, we found that SGT1 is not limiting for early PRR-dependent responses or antibacterial immunity. We therefore conclude that SGT1 does not play a significant role in bacterial PAMP-triggered immunity.
植物免疫信号的激活是通过感知病原体相关分子模式（PAMPs）或效应蛋白来介导的，这些信号的激活是由模式识别受体（PRRs）和核苷酸结合和富含亮氨酸重复域受体（NLRs）介导的，它们通常共享细胞成分和下游反应。许多 PRRs 是富含亮氨酸重复的受体样激酶（LRR-RLKs），它们主要感知蛋白 PAMPs。抑制 skp1 的 G2 等位基因（SGT1）是 NLR 介导的免疫激活所必需的核心免疫调节剂。在这项工作中，我们研究了 SGT1 在烟草原生质体和拟南芥中几种 LRR-RLKs 介导的免疫反应中的必要性。使用互补的遗传方法，我们发现 SGT1 并不限制早期 PRR 依赖的反应或抗菌免疫。因此，我们得出结论，SGT1 在细菌 PAMP 触发的免疫中没有发挥重要作用。
