Timsit M, Timsit-Berthier M, Schoenen J, Maertens de Noordhout A
Laboratoire de Neurophysiologie clinique et de Psychopathologie, Université de Liège, Belgique.
Rev Electroencephalogr Neurophysiol Clin. 1987 Sep;17(3):259-70. doi: 10.1016/s0370-4475(87)80063-1.
The aim of this study was to display the result obtained by the contingent negative variation (CNV) recording in patients suffering from headache. Eighty-five patients were taken into account: 59 with migraines (M) and 26 with tension headache (TH). A typical CNV pattern (high CNV amplitude with no habituation) differentiated M from TH. Moreover, psychological data were collected through Rorschach ink blot test among 42 headache sufferers (31 M and 11 TH). The typical Rorschach repressive pattern of alexithymia was found as well in M as in TH while CNV amplitude was significantly higher in the 31 M (-25 microV) than in the 11 TH (-19 microV FP less than 0.04). Biochemical data collected among 28 patients (17 M and 11 TH) revealed a positive correlation between CNV amplitude and plasma level of noradrenaline, regardless of the type of headache (r = 0.58; P less than 0.01). Thus, besides psychological factors, catecholaminergic mechanisms seem implicated in the determination of the CNV pattern in migraine. CNV may help the clinician both to specify diagnosis and to decide between the many therapeutic strategies available.
本研究的目的是展示对头痛患者进行关联性负变（CNV）记录所获得的结果。共纳入85例患者：59例偏头痛（M）患者和26例紧张性头痛（TH）患者。典型的CNV模式（高CNV波幅且无习惯化现象）可区分偏头痛与紧张性头痛。此外，对42例头痛患者（31例偏头痛患者和11例紧张性头痛患者）通过罗夏墨迹测验收集心理数据。在偏头痛患者和紧张性头痛患者中均发现了典型的述情障碍罗夏压抑模式，而31例偏头痛患者的CNV波幅（-25微伏）显著高于11例紧张性头痛患者（-19微伏，P<0.04）。在28例患者（17例偏头痛患者和11例紧张性头痛患者）中收集的生化数据显示，无论头痛类型如何，CNV波幅与去甲肾上腺素血浆水平之间均呈正相关（r = 0.58；P<0.01）。因此，除心理因素外，儿茶酚胺能机制似乎也参与了偏头痛患者CNV模式的决定过程。CNV可能有助于临床医生明确诊断，并在多种可用治疗策略之间做出抉择。
