Besken E, Pothmann R, Sartory G
Department of Clinical Psychology, University of Wuppertal, Germany.
Cephalalgia. 1993 Feb;13(1):42-3. doi: 10.1046/j.1468-2982.1993.1301042.x.
Adult migraineurs without aura have an increased amplitude of the Contingent Negative Variation (CNV) between attacks. Given the potential diagnostic importance of this finding and the difficulties associated with diagnosing migraine in childhood it seemed important to assess CNV in children suffering from this disorder. Ninety-seven children aged between 8 and 14 years were recruited. Forty-two suffered from migraine, 34 from tension-type headache. Twenty-one healthy controls were also studied. CNV was recorded from Fz, Cz and Pz referenced to linked earlobes during 20 trials consisting of two tones of moderate intensity with an interstimulus interval (ISI) of 4 sec and an intertrial interval (ITI) of 10 to 14 sec. The second tone of each trial required a button press. EOG was recorded from the left eye. The 10 CNV responses with the least EOG artefact were selected and averaged. Children with migraine had a highly significantly more negative mean CNV amplitude at all three electrode sites than children with tension-type headache and also a more pronounced Post-Imperative-Negative-Variation (PINV). Migrainous children differed from controls only at Cz (ISI). There was also a highly significant increase of mean CNV amplitude and PINV at all three electrode sites in the control group compared to the tension headache group.
无先兆成年偏头痛患者发作间期的关联性负变（CNV）波幅增加。鉴于这一发现的潜在诊断重要性以及儿童偏头痛诊断的困难，评估患有这种疾病的儿童的CNV似乎很重要。招募了97名8至14岁的儿童。其中42名患有偏头痛，34名患有紧张型头痛。还研究了21名健康对照者。在20次试验中，以耳垂为参考电极，从Fz、Cz和Pz记录CNV，试验由两个中等强度的音调组成，刺激间隔（ISI）为4秒，试验间隔（ITI）为10至14秒。每次试验的第二个音调需要按键。从左眼记录眼电图（EOG）。选择10个EOG伪迹最少的CNV反应并进行平均。偏头痛儿童在所有三个电极部位的平均CNV波幅均显著低于紧张型头痛儿童，且其指令后负变（PINV）更为明显。偏头痛儿童仅在Cz（ISI）部位与对照组不同。与紧张性头痛组相比，对照组在所有三个电极部位的平均CNV波幅和PINV也显著增加。
