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社区居住的老年门诊患者原发性肌肉减少症的患病率及危险因素:一项横断面研究。

Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study.

机构信息

Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.

Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.

出版信息

Sci Rep. 2020 Nov 11;10(1):19551. doi: 10.1038/s41598-020-75250-y.

Abstract

No previous study has investigated the prevalence and risk factors for primary sarcopenia in outpatient setting. This study aims to evaluate the prevalence and factors associated with primary sarcopenia in outpatient elderly. Additionally, we compared the severity of sarcopenia based on the 2014 and 2019 Asian Working Group for Sarcopenia (AWGS) criteria. This cross-sectional study was performed in 330 subjects aged over 60 years in an outpatient setting. The muscle strength, muscle performance and muscle mass were assessed using the handheld dynamometer, 6-m gait speed, and bioelectrical impedance analysis, respectively. The prevalence of sarcopenia was 10% as per the 2014 and 2019 AWGS criteria. The development of sarcopenia was positively correlated with the age with an odds ratio (OR) of 6.87 [95% confidence interval (CI) 1.63-28.88] in the middle-old group (70-79 years), and 13.71 (95%CI 3.66-51.41; p = 0.009) in the very old group (≥ 80 years). Prefrailty and low physical activity were significantly associated with sarcopenia with an OR of 4.75 (95%CI 1.90-11.89) in prefrailty, 15.35 (95%CI 1.69-139.47) in the middle activity group, and 17.99 (95%CI 1.95-165.73) in the lowest activity group. In conclusion, primary sarcopenia was found in one-tenth of outpatient elderly. Age, prefrailty, and low activity were independent factors associated with sarcopenia.

摘要

先前的研究并未调查门诊环境下原发性肌少症的患病率和危险因素。本研究旨在评估门诊老年患者原发性肌少症的患病率和相关因素。此外,我们比较了基于 2014 年和 2019 年亚洲肌少症工作组(AWGS)标准的肌少症严重程度。这是一项在门诊 330 名 60 岁以上患者中进行的横断面研究。使用手持测力计评估肌肉力量,6 米步行速度评估肌肉性能,生物电阻抗分析评估肌肉质量。根据 2014 年和 2019 年 AWGS 标准,肌少症的患病率分别为 10%。肌少症的发生与年龄呈正相关,中老年人组(70-79 岁)的优势比(OR)为 6.87(95%置信区间(CI)为 1.63-28.88),非常老年人组(≥80 岁)的 OR 为 13.71(95%CI 为 3.66-51.41;p=0.009)。衰弱前期和低体力活动与肌少症显著相关,衰弱前期的 OR 为 4.75(95%CI 为 1.90-11.89),中体力活动组的 OR 为 15.35(95%CI 为 1.69-139.47),低体力活动组的 OR 为 17.99(95%CI 为 1.95-165.73)。总之,门诊老年患者中有十分之一患有原发性肌少症。年龄、衰弱前期和低活动是与肌少症相关的独立因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe37/7658996/df9f36b03adb/41598_2020_75250_Fig1_HTML.jpg

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