Leong Andrew F T, Gang Grace J, Sisniega Alejandro, Wang Wenying, Wu Jesse, Bambot Shabbir, Stayman J Webster
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA.
Fischer Imaging, West Hills, CA USA.
Proc SPIE Int Soc Opt Eng. 2020 Feb;11312. doi: 10.1117/12.2550200. Epub 2020 Mar 16.
Mammography and breast CT are important tools for breast cancer screening and diagnosis. Current implementations are limited by scattered radiation and/or spatial resolution. In this work, we propose and develop a slot scan-based system to be used in both mammography and CT mode that can limit scatter and collect sparse CT data for improved image quality at low radiation exposures. Monte Carlo simulations of an anthropomorphic breast phantom show a factor of 10 reduction in scattering amplitude with our slot scan-based system compared to that of a full-field detector mammography system (area mode). Similarly, slot-scan improved the MTF (particularly the low-frequency response) compared to an area detector. Investigation of sparse CT sampling with doubly sparse acquisition data return better quality reconstruction, for which our slot-scanning system is capable, over angle-only projection. Thus, a system with the combined ability for slot-scanning mammography and slot-scanning breast CT has the potential to deliver improved dose-efficient imaging performance and become viable breast cancer screening and diagnostic tools.
乳腺钼靶摄影和乳腺CT是乳腺癌筛查和诊断的重要工具。当前的技术在散射辐射和/或空间分辨率方面存在局限性。在这项工作中，我们提出并开发了一种基于狭缝扫描的系统，该系统可用于乳腺钼靶摄影和CT模式，能够限制散射并收集稀疏的CT数据，以便在低辐射剂量下提高图像质量。对人体乳腺模型的蒙特卡罗模拟表明，与全场探测器乳腺钼靶摄影系统（面积模式）相比，我们基于狭缝扫描的系统的散射幅度降低了10倍。同样，与面积探测器相比，狭缝扫描改善了调制传递函数（特别是低频响应）。对具有双稀疏采集数据的稀疏CT采样的研究表明，与仅角度投影相比，我们的狭缝扫描系统能够实现质量更好的重建。因此，一种具有狭缝扫描乳腺钼靶摄影和狭缝扫描乳腺CT综合能力的系统有可能提供更高的剂量效率成像性能，并成为可行的乳腺癌筛查和诊断工具。
