Antibiotic resistance profiles of serotypes isolated from animals in Iran: a meta-analysis.

BACKGROUND

infection (salmonellosis) is a zoonotic bacterial disease. Widespread use of antibiotics in livestock and poultry production for different purposes such as treatment and growth promotion has led to the emergence of antibiotic-resistant , causing treatment of infections more difficult with each passing year.

AIMS

To determine the antibiotic resistance prevalence of serotypes isolated from animals in different provinces of Iran.

METHODS

To find eligible articles, we searched the international and national electronic databases using appropriate keywords in English and Persian.

RESULTS

After applying predefined criteria, 54 articles reporting antibiotic resistance profiles of serotypes were included. isolates were mostly resistant against nalidixic acid (67%), tetracycline (66.9%), and streptomycin (49.6%), followed by trimethoprim/sulfamethoxazole (41.6%) and kanamycin (23.6%). The highest sensitivity was observed against imipenem, meropenem, and cefepime with 1.7%, 1.4%, and 1.9% of all isolates being resistant, respectively.

CONCLUSION

Results revealed that the prevalence of resistant isolates to nalidixic acid, tetracycline and streptomycin is high and their use must be restricted. In addition, resistance to other antibiotics such as chloramphenicol, ampicillin, cephalothin, cefixime, and enrofloxacin is at an alarming level that calls for attention in the future infection control and antibiotic stewardship programs.