Qin Xiaojie, Yang Mingzhe, Cai Hua, Liu Yangtai, Gorris Leon, Aslam Muhammad Zohaib, Jia Kai, Sun Tianmei, Wang Xiang, Dong Qingli
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Antibiotics (Basel). 2022 Apr 16;11(4):532. doi: 10.3390/antibiotics11040532.
Antibiotic resistance in is a global public health problem. serovar 1,4,[5],12:i:- (. 1,4,[5],12:i:-), a monophasic variant of Typhmurium, is one of the leading serovars in several countries. This study aimed to assess the prevalence of antibiotic resistance to this serovar in China through a systematic review and meta-analysis. Nineteen eligible studies during 2011-2021 were included. A total of 4514 isolates from humans, animals, foods, and the environment were reported, which mainly concerned isolates found in Guangdong, Guangxi, Jiangsu, and Shanghai. A random-effects model was used to estimate the pooled resistance rate of . 1,4,[5],12:i:-. Rates were found to be very high (values ≥ 75%) for tetracycline, ampicillin, sulfisoxazole, and streptomycin; high (50-75%) for nalidixic acid, amoxicillin-clavulanic acid, and chloramphenicol; and moderate (25-50%) for trimethoprim-sulfamethoxazole, kanamycin, trimethoprim, and gentamicin. The rates of resistance to ciprofloxacin, cefotaxime, ceftriaxone, cefepime, ceftazidime, and colistin were low (values ≤ 25%), but of great concern in terms of their current clinical importance. Furthermore, a high multidrug resistance rate (86%, 95% CI: 78-92%) was present in . 1,4,[5],12:i:-, with the ASSuT pattern largely dominating. Subgroup analysis results showed that the high heterogeneity of resistance rates was not entirely dependent on isolated sources. Taken together, the severity of antibiotic resistance in . 1,4,[5],12:i:- urgently requires the rational use of antibiotics in future infection control and antibiotic stewardship programs.
[鼠伤寒沙门氏菌]1,4,[5],12:i:-血清型的抗生素耐药性是一个全球公共卫生问题。[鼠伤寒沙门氏菌]1,4,[5],12:i:-血清型是鼠伤寒沙门氏菌的单相变体，是多个国家主要的沙门氏菌血清型之一。本研究旨在通过系统评价和荟萃分析评估中国该血清型的抗生素耐药性流行情况。纳入了2011年至2021年期间的19项符合条件的研究。共报告了4514株来自人类、动物、食品和环境的分离株，主要涉及在广东、广西、江苏和上海发现的分离株。采用随机效应模型估计[鼠伤寒沙门氏菌]1,4,[5],12:i:-血清型的合并耐药率。发现四环素、氨苄西林、磺胺异恶唑和链霉素的耐药率非常高（值≥75%）；萘啶酸、阿莫西林-克拉维酸和氯霉素的耐药率较高（50-75%）；甲氧苄啶-磺胺甲恶唑、卡那霉素、甲氧苄啶和庆大霉素的耐药率中等（25-50%）。对环丙沙星、头孢噻肟、头孢曲松、头孢吡肟、头孢他啶和黏菌素的耐药率较低（值≤25%），但就其当前的临床重要性而言令人高度关注。此外，[鼠伤寒沙门氏菌]1,4,[5],12:i:-血清型存在较高的多重耐药率（86%，95%CI：78-92%），以ASSuT模式为主。亚组分析结果表明，耐药率的高度异质性并不完全取决于分离来源。综上所述，[鼠伤寒沙门氏菌]1,4,[5],12:i:-血清型抗生素耐药性的严重性迫切需要在未来的感染控制和抗生素管理计划中合理使用抗生素。
