Okaiyeto Kunle, Falade Ayodeji Osmund, Oguntibeju Oluwafemi Omoniyi
Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa.
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo 351101, Ondo State, Nigeria.
Plants (Basel). 2021 Sep 13;10(9):1893. doi: 10.3390/plants10091893.
is an underutilized leafy vegetable consumed in some parts of Nigeria. The interest in has continued to increase due to its multipurpose values, including traditional uses, nutritional properties, and some therapeutic potentials; however, the pharmacological prospects of the plant are yet to be fully explored. Therefore, in the present review, different databases such as PubMed, Scopus, Web of Science, Google Scholar, etc. were explored to retrieve publications used to write this review. The pharmacological potentials of such as anticancer, antioxidant, antiviral, antimicrobial, anti-inflammatory, hepatoprotective, antidiabetic, and anti-hypertensive properties, were highlighted. The toxicological potential of the plant is also discussed. Proposed mechanisms that underline its biological activities include modulation of redox homeostasis, leading to decreased oxidative stress; down-regulation of matrix metalloproteinase-9 (MMP-9) expression; inhibition of key enzymes implicated in diabetes mellitus, hypertension, and neurological diseases; and inhibition of oxidative burst and inflammatory cytokines. Furthermore, the prospect of endophytes from as a bioresource to produce novel therapeutic agents, as well as the development of nanotherapeutics from the plant extracts and its phytoconstituents, are discussed. In conclusion, possesses an enormous number of possible pharmacological properties and therapeutic potentials waiting to be explored.
是尼日利亚某些地区食用但未得到充分利用的叶菜类蔬菜。由于其具有多种用途，包括传统用途、营养特性和一些治疗潜力，人们对它的兴趣持续增加；然而，该植物的药理学前景尚未得到充分探索。因此，在本综述中，我们检索了不同的数据库，如PubMed、Scopus、科学网、谷歌学术等，以获取用于撰写本综述的出版物。文中强调了该植物的药理学潜力，如抗癌、抗氧化、抗病毒、抗菌、抗炎、保肝、抗糖尿病和抗高血压特性。还讨论了该植物的毒理学潜力。其生物活性背后的潜在机制包括调节氧化还原稳态，导致氧化应激降低；下调基质金属蛋白酶-9（MMP-9）的表达；抑制与糖尿病、高血压和神经疾病相关的关键酶；以及抑制氧化爆发和炎性细胞因子。此外，还讨论了该植物内生菌作为生产新型治疗剂生物资源的前景，以及从植物提取物及其植物成分开发纳米疗法的前景。总之，该植物具有大量有待探索的潜在药理学特性和治疗潜力。
