Lademann Franziska, Hofbauer Lorenz C, Rauner Martina
Department of Medicine III, Technische Universität Dresden, Dresden, Germany.
Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany.
Front Cell Dev Biol. 2020 Oct 16;8:586031. doi: 10.3389/fcell.2020.586031. eCollection 2020.
Bone health crucially relies on constant bone remodeling and bone regeneration, both tightly controlled processes requiring bone formation and bone resorption. Plenty of evidence identifies bone morphogenetic proteins (BMP) as major players in osteoblast differentiation and thus, bone formation. However, in recent past years, researchers also increasingly reported on the pivotal role of these multi-functional growth factors in osteoclast formation and activity. This review aims to summarize the current knowledge of BMP signaling within the osteoclast lineage, its role in bone resorption, and osteoblast-osteoclast coupling. Furthermore, subsequent clinical implications for recombinant BMP therapy will be discussed in view of recent preclinical and clinical studies.
骨骼健康关键依赖于持续的骨重塑和骨再生，这两个过程都受到严格控制，需要骨形成和骨吸收。大量证据表明骨形态发生蛋白（BMP）是成骨细胞分化以及骨形成的主要参与者。然而，在过去几年中，研究人员也越来越多地报道了这些多功能生长因子在破骨细胞形成和活性中的关键作用。本综述旨在总结目前关于破骨细胞谱系中BMP信号传导的知识、其在骨吸收中的作用以及成骨细胞 - 破骨细胞偶联。此外，鉴于最近的临床前和临床研究，还将讨论重组BMP治疗的后续临床意义。
