Department of Cardiovascular Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Kumamoto, Japan.
Department of Pathophysiology, Oita University School of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Heart Vessels. 2021 Apr;36(4):577-588. doi: 10.1007/s00380-020-01724-8. Epub 2020 Nov 12.
This investigation was aimed to identify gene profiles in human atrial myocardium in response to chronic mechanical stretch. Right atrial appendages from 21 patients were divided into 2 groups based on the size of right atrial volume. The microarray DATA analyses differentially identified 335 genes (> 2.0-fold, corrected P < 0.05) including "functionally unknown genes". This study identified 26 up-regulated genes (natriuretic peptide B, G protein subunit gamma 13, thyroid stimulating hormone beta, etc.) and 23 down-regulated genes (oligodendrocyte transcription factor 1, carbonic anhydrase 12, etc.), which could be responsible for chronic stretch-mediated structural remodeling in the atrium.
本研究旨在鉴定人类心房心肌对慢性机械拉伸的基因谱反应。根据右心房容积大小，将 21 例患者的右心耳分为 2 组。微阵列 DATA 分析差异鉴定出 335 个基因（> 2.0 倍，校正 P < 0.05），包括“功能未知基因”。本研究鉴定出 26 个上调基因（脑钠肽 B、G 蛋白亚基 γ13、促甲状腺激素β等）和 23 个下调基因（少突胶质细胞转录因子 1、碳酸酐酶 12 等），这些基因可能负责心房中介导慢性拉伸的结构重塑。
