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检测和识别高血压患者心房中负责血压调节的因素。

Detection and identification of factors in the atrium responsible for blood pressure regulation in patients with hypertension.

机构信息

Department of Pathophysiology, Oita University School of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.

Department of Cardiovascular Surgery, Oita University School of Medicine, Oita University, Yufu, Oita, Japan.

出版信息

Heart Vessels. 2024 May;39(5):464-474. doi: 10.1007/s00380-024-02362-0. Epub 2024 Mar 7.

DOI:10.1007/s00380-024-02362-0
PMID:38451262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11006736/
Abstract

Resection of the left atrial appendage reportedly improves blood pressure in patients with hypertension. This study aimed to validate the transcriptional profiles of atrial genes responsible for blood pressure regulation in patients with hypertension as well as to identify the molecular mechanisms in rat biological systems. RNA sequencing data of left atrial appendages from patients with (n = 6) and without (n = 6) hypertension were subjected to unsupervised principal component analysis (PCA). Reduction of blood pressure was reflected by third and ninth principal components PC3 and PC9, and that eighteen transcripts, including endothelin-1, were revealed by PCA-based pathway analysis. Resection of the left atrial appendage in hypertensive rats improved their blood pressure accompanied by a decrease in serum endothelin-1 concentration. Expression of the endothelin-1 gene in the atrium and atrial appendectomy could play roles in blood pressure regulation in humans and rats.

摘要

据报道，左心耳切除术可改善高血压患者的血压。本研究旨在验证与高血压患者血压调节相关的心房基因的转录谱，并鉴定大鼠生物系统中的分子机制。对有（n=6）和无（n=6）高血压的患者的左心耳的 RNA 测序数据进行无监督主成分分析（PCA）。血压的降低反映在第三和第九主成分 PC3 和 PC9 上，并且通过基于 PCA 的途径分析揭示了包括内皮素-1 在内的十八个转录物。在高血压大鼠中切除左心耳可降低其血压，同时降低血清内皮素-1浓度。心房和左心耳切除术的内皮素-1基因表达可能在人类和大鼠的血压调节中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/594898612076/380_2024_2362_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/6b8c65287c93/380_2024_2362_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/594898612076/380_2024_2362_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/86d88bd57f4f/380_2024_2362_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/c8e63ea52053/380_2024_2362_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/5b117d5d8b17/380_2024_2362_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/40a9e293e580/380_2024_2362_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/546f80b802e8/380_2024_2362_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/6b8c65287c93/380_2024_2362_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee3b/11006736/594898612076/380_2024_2362_Fig7_HTML.jpg

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本文引用的文献

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Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats.内皮素受体阻断对自发性高血压大鼠左心房组织的抗炎作用。
Int J Cardiol Heart Vasc. 2022 Jul 20;42:101088. doi: 10.1016/j.ijcha.2022.101088. eCollection 2022 Oct.
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Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension.
原发性高血压患者血浆内皮素-1和大内皮素-1水平
Pathophysiology. 2021 Oct 25;28(4):489-495. doi: 10.3390/pathophysiology28040031.
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Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis: .心外膜左心耳结扎对全身止血的长期影响：
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JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias.《日本循环学会/日本心律学会2020年心律失常药物治疗指南》
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