Department of Otorhinolaryngology and Sleep Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
Department of Otorhinolaryngology and Sleep Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
Med Hypotheses. 2018 Jan;110:138-143. doi: 10.1016/j.mehy.2017.12.004. Epub 2017 Dec 5.
Obstructive sleep apnea is known to be associated with diseases such as hypertension, metabolic disorder, and cancer. A more controversial and less understood association is that of sleep apneas and the development and worsening of autoimmune and rheumatologic disorders. Through the main pathways of intermittent hypoxia and sleep deprivation, we hypothesize that obstructive sleep apnea creates a chronic inflammatory state that worsens or incites autoimmune disorders. This thorough review of the available literature highlights our current understanding of the relationship between these disease processes in order to demonstrate the importance of diagnosis and appropriate management of sleep disorders in patients suffering from rheumatologic diseases.
阻塞性睡眠呼吸暂停与高血压、代谢紊乱和癌症等疾病有关。一个更有争议且不太被理解的关联是睡眠呼吸暂停与自身免疫和风湿性疾病的发展和恶化有关。通过间歇性缺氧和睡眠剥夺的主要途径，我们假设阻塞性睡眠呼吸暂停会导致慢性炎症状态，从而使自身免疫性疾病恶化或引发自身免疫性疾病。对现有文献的全面回顾强调了我们目前对这些疾病过程之间关系的理解，以证明诊断和适当管理睡眠障碍对患有风湿性疾病的患者的重要性。
