Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, LA, USA.
Medicine (Baltimore). 2021 Feb 12;100(6):e24659. doi: 10.1097/MD.0000000000024659.
Some studies have demonstrated an increased risk of prostate cancer in patients with obstructive sleep apnea (OSA). However, the relationship is unclear and the results are conflicting. This study aims to investigate associations between OSA and prostate cancer using the Korea National Health Insurance Service database.A total of 152,801 men (≥ 20 years of age) newly diagnosed with OSA between 2007 and 2014 were included. A control group of 764,005 subjects was selected using propensity score matching by age and sex. The mean follow-up time was 4.6 years (range 2.3-6.9). The primary endpoint was newly diagnosed prostate cancer. The prostate cancer hazard ratio (95% confidence interval) was calculated for patients with OSA and compared to the control group.The incidence of prostate cancer among patients with OSA was significantly higher than that in controls (1.34 [1.23-1.49]). In particular, the incidence of prostate cancer was highest in patients aged 40-65 years (1.51 [1.32-1.72]).This study provides additional evidence for a link between OSA and prostate cancer.
一些研究表明，阻塞性睡眠呼吸暂停（OSA）患者患前列腺癌的风险增加。然而，这种关系并不明确，结果也存在矛盾。本研究旨在使用韩国国家健康保险服务数据库研究 OSA 与前列腺癌之间的关联。
共有 152801 名（≥ 20 岁）2007 年至 2014 年间新诊断为 OSA 的男性被纳入研究。通过年龄和性别进行倾向评分匹配，选择了 764005 名对照组受试者。平均随访时间为 4.6 年（范围 2.3-6.9）。主要终点是新诊断的前列腺癌。计算了 OSA 患者的前列腺癌风险比（95%置信区间），并与对照组进行了比较。
OSA 患者的前列腺癌发病率明显高于对照组（1.34 [1.23-1.49]）。特别是，40-65 岁患者的前列腺癌发病率最高（1.51 [1.32-1.72]）。
本研究为 OSA 和前列腺癌之间的联系提供了额外的证据。
