Kawaoi A, Moriyama S
Department of Pathology, Yamanashi Medical College, Japan.
Acta Pathol Jpn. 1987 Sep;37(9):1455-63.
The functional aspects of DIPN induced rat thyroid lesions classified as in our previous studies were analyzed by immunohistochemical detection of Tg, T4, and T3 in serial or semi-serial paraffin sections. The type 1 lesions, i.e., foci of cellular alteration of individual follicles, showed the same pattern of immunostaining as seen in the surrounding hyperplastic follicles and in normal controls. On the other hand, the type 3 lesions, i.e., carcinomas, were mostly negative for T4 and T3 with only partial staining for Tg. The type 2 lesions, i.e. proliferative nodules, which might include a state of nodular hyperplasia as well as benign neoplastic nodules, demonstrated intermediate stainability between the type 1 and type 3 lesions. These results suggest that the histological structures of focal lesions of the thyroid gland may be closely related to their functional activities. Also, the importance of follicular structure formation in thyroid hormone synthesis was demonstrated in each type of focal lesion.
通过对连续或半连续石蜡切片中Tg、T4和T3进行免疫组织化学检测，分析了在我们之前的研究中分类的DIPN诱导的大鼠甲状腺病变的功能方面。1型病变，即单个滤泡的细胞改变灶，显示出与周围增生性滤泡和正常对照相同的免疫染色模式。另一方面，3型病变，即癌，T4和T3大多为阴性，Tg仅部分染色。2型病变，即增生性结节，可能包括结节性增生状态以及良性肿瘤性结节，在1型和3型病变之间表现出中等染色性。这些结果表明，甲状腺局灶性病变的组织结构可能与其功能活动密切相关。此外，在每种类型的局灶性病变中都证明了滤泡结构形成在甲状腺激素合成中的重要性。
