Kawaoi A, Moriyama S
Department of Pathology, Yamanashi Medical College, Japan.
Acta Pathol Jpn. 1987 Sep;37(9):1441-53. doi: 10.1111/j.1440-1827.1987.tb02266.x.
An ultrastructural study was carried out on DIPN induced lesions of rat thyroid glands, in order to characterize in detail each type or subtype as classified by light microscopy in our previous report. Organelles closely related to the endocrine function of the thyroid epithelium such as apical or subapical vesicles, lysosomal granules, colloid droplets, Golgi apparatus, rER, and microvilli on the apical surface, were found to decrease in parallel with structural and cellular atypism of the thyroid lesion under examination, suggesting impairment of their function in the malignant lesions. On the other hand, observations of transitional forms among the lesions in term of the subcellular structure were considered to support the possibility that transformation from one type to another could occur.
为了详细描述我们之前报告中通过光学显微镜分类的每种类型或亚型，对二异丙基二硫代磷酸酯（DIPN）诱导的大鼠甲状腺损伤进行了超微结构研究。发现与甲状腺上皮内分泌功能密切相关的细胞器，如顶端或顶端下囊泡、溶酶体颗粒、胶体小滴、高尔基体、粗面内质网和顶端表面的微绒毛，与所检查的甲状腺病变的结构和细胞异型性平行减少，这表明它们在恶性病变中的功能受损。另一方面，从亚细胞结构角度观察病变中的过渡形式被认为支持了一种可能性，即可能发生从一种类型到另一种类型的转变。
