Dept of Physical Medicine and Rehabilitation, Ege University Faculty of Medicine , Izmir, Turkey.
Dept. of Physical Medicine and Rehabilitation, Hacettepe University Faculty of Medicine , Ankara, Turkey.
Exp Aging Res. 2021 Jan-Feb;47(1):79-91. doi: 10.1080/0361073X.2020.1846949. Epub 2020 Nov 12.
: To investigate the association of polypharmacy with physical function, nutritional status, and depression in the elderly. : The study included 675 people aged over 65 years from 8 centers in various geographical regions. The polypharmacy status was categorized as non-polypharmacy (0-4 drugs), polypharmacy (≥5 drugs). The subjects' physical function was assessed based on their "physical activity levels, Holden ambulation scores, gait speeds, and hand grip strengths"; their nutritional status based on the "Mini Nutritional Assessment (MNA)"; and their psychological status based on the "Center for Epidemiologic Studies Depression Scale -CES-D". : The presence of polypharmacy in this population was found to be 30% (n = 203). A statistically significant difference was found between the groups on the level of physical activity, Holden ambulation score, and nutrition status ( < .05). There was a statistically significant difference between the groups also on hand grip strength, MNA score, Charlson score ( < .05). : Polypharmacy was observed to have a significant association with physical function, nutrition, and depression in the elderly aged ≥ 65 years.
探讨老年人药物多种应用与身体机能、营养状况和抑郁之间的关系。
本研究纳入了来自 8 个不同地理位置中心的 675 名 65 岁以上的老年人。药物多种应用的状态分为非药物多种应用（0-4 种药物）和药物多种应用（≥5 种药物）。基于“身体活动水平、Holden 步态评分、步态速度和手握力”评估受试者的身体机能；基于“微型营养评估（MNA）”评估其营养状况；基于“流行病学研究中心抑郁量表-CES-D”评估其心理状况。
在该人群中，药物多种应用的发生率为 30%（n=203）。两组在身体活动水平、Holden 步态评分和营养状况方面存在统计学差异（<0.05）。两组在手握力、MNA 评分和 Charlson 评分方面也存在统计学差异（<0.05）。
≥65 岁的老年人中，药物多种应用与身体机能、营养和抑郁显著相关。
