Jhingta Pravesh Kumar, Mardi Kavita, Sharma Deepak, Bhardwaj Vinay Kumar, Bhardwaj Ashu, Saroch Nitin, Negi Nishant
Department of Periodontology, H.P. Government Dental College and Hospital, Shimla, India.
Department of Pathology, Indira Gandhi Medical College and Hospital, Shimla, India.
Contemp Clin Dent. 2018 Jan-Mar;9(1):132-136. doi: 10.4103/ccd.ccd_816_17.
Plasma cell granuloma is a rare benign lesion characterized by the infiltration of plasma cells; primarily occurring in the lungs. It is also seen to occur in the brain, kidney stomach, heart, and so on but its intraoral occurrence is a rarity. This case report represents one of the uncommon locations in the oral cavity affected by plasma cell granuloma, its clinical and histological features, and establishes the differential diagnosis with other malignant or benign disease entities and planning the treatment accordingly. This report discusses the diagnostic enigma and the associated terminology of plasma cell granulomas and reinforces the need for performing biopsy and a histopathological or immune histochemical study, irrespective of the clinical features and clinical diagnosis of the lesion. In this case a 52-year-old female, presented with gingival enlargement in the mandibular anterior region, treated by excisional biopsy. Histological evaluation revealed plasma cell infiltrates in the connective tissue. The immune-histochemistry revealed kappa and lambda light chains with a polyclonal staining pattern, which confirmed the diagnosis of plasma cell granuloma.
浆细胞性肉芽肿是一种罕见的良性病变，其特征为浆细胞浸润，主要发生于肺部。它也可见于脑、肾、胃、心脏等部位，但其发生于口腔内则较为罕见。本病例报告介绍了浆细胞性肉芽肿累及口腔的一个不常见部位、其临床和组织学特征，并与其他恶性或良性疾病实体进行鉴别诊断，从而相应地制定治疗方案。本报告讨论了浆细胞性肉芽肿的诊断难题及相关术语，并强调无论病变的临床特征和临床诊断如何，均需进行活检及组织病理学或免疫组织化学研究。在本病例中，一名52岁女性因下颌前部牙龈肿大就诊，接受了切除活检。组织学评估显示结缔组织中有浆细胞浸润。免疫组织化学显示κ和λ轻链呈多克隆染色模式，从而确诊为浆细胞性肉芽肿。
