Department of Stomatology, Affiliated Hospital of Putian University, Putian, Fujian 351100, China.
J Nanosci Nanotechnol. 2021 Feb 1;21(2):1107-1117. doi: 10.1166/jnn.2021.18679.
Recurrent oral ulcer is a common oral mucosal disease. Due to its periodic and recurrent characteristics, the onset of burning pain is unbearable, which brings great inconvenience to the patient's life and seriously affects the patient's quality of life. There are certain limitations to conventional drug therapy. With the rapid development of nanotechnology, the obvious advantages of nanotechnology such as targeting, controlled release, biocompatibility is obviously shown. The combination of nanotechnology and medical research has led to the emergence of polymer nanoparticles and ligands. Nano-drugs for gene therapy, and many other new nano-drug carriers, polymer micelle is a new type of nano drug carrier that has appeared in recent years. It has both a hydrophilic shell and a hydrophobic core, and has a variety of excellent properties, such as higher stability and , and poorly soluble drugs. In this paper, a new method for treating recurrent oral ulcers based on a new nano-drug carrier was studied. Because of the hydrophilicity and biocompatibility of oral cell surface proteins, the research progress of nanopharmaceutical carrier in the treatment of recurrent oral ulcers is reviewed. The experimental results show that the method has good reproducibility and high efficiency in the treatment of recurrent oral ulcers. It is used to explore the application and progress of nanotechnology in the diagnosis and treatment of recurrent oral ulcers, and to provide new ideas for the clinical diagnosis and treatment of recurrent oral ulcers. This new technical method has wide practical application value.
复发性口腔溃疡是一种常见的口腔黏膜疾病。由于其周期性和复发性的特点,发病时灼痛难忍,给患者的生活带来极大不便,严重影响患者的生活质量。常规药物治疗存在一定局限性。随着纳米技术的快速发展,纳米技术的靶向、控制释放、生物相容性等明显优势明显显现。纳米技术与医学研究的结合,催生了聚合物纳米粒和配体等纳米药物载体、基因治疗的纳米药物,以及许多其他新型纳米药物载体。聚合物胶束是近年来出现的新型纳米药物载体。它具有亲水性外壳和疏水性内核,具有多种优良的性能,如更高的稳定性和对难溶性药物的增溶作用。本文研究了一种基于新型纳米药物载体的复发性口腔溃疡治疗新方法。由于口腔细胞表面蛋白的亲水性和生物相容性,综述了纳米药物载体在复发性口腔溃疡治疗中的研究进展。实验结果表明,该方法在治疗复发性口腔溃疡方面具有良好的重现性和高效性。用于探索纳米技术在复发性口腔溃疡的诊断和治疗中的应用和进展,为复发性口腔溃疡的临床诊断和治疗提供新的思路。这种新的技术方法具有广泛的实际应用价值。