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基于纳米银抗菌敷料的糖尿病足溃疡治疗研究。

Research on the Treatment of Diabetic Foot with Ulcer Based on Nano-Silver Antibacterial Dressing.

机构信息

Department of General Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China.

Radiology Department, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China.

出版信息

J Nanosci Nanotechnol. 2021 Feb 1;21(2):1220-1229. doi: 10.1166/jnn.2021.18680.

Abstract

The incidence of diabetes has been increasing year by year. Long-term growth in blood sugar causes complications such as diabetic foot ulcer and infections, which will increase the difficulty of ulcer treatment. The diabetes brings great pain and heavy economic burden to patients and their families. In view of the above problems, a nano-silver antibacterial dressing is synthesized in this paper to control bacterial infection on the ulcer surface and promote wound healing. This paper describes the preparation process and morphological characterization of nano-silver antibacterial dressings. 100 patients were selected, which divided into two groups for comparative experiments. The conventional group used conventional vaseline dressing, and the control group was nano-silver antibacterial dressing. The ulcer surface healing time, the number of dressing changes, and the control of infection were analyzed separately, and statistical analysis was performed with SPSS19.0. The experimental results are as follows. The use of nano-silver antibacterial dressing can significantly reduce the incidence of infection in diabetic foot patients, which is helpful to reduce the number of dressing changes, shorten the healing time of ulcer, and accelerate the turnover rate. It helps to shorten the course of diabetic foot, and it is recommended to promote its clinical application.

摘要

糖尿病的发病率逐年上升。长期的血糖升高会导致糖尿病足溃疡和感染等并发症,这会增加溃疡治疗的难度。糖尿病给患者及其家庭带来了巨大的痛苦和沉重的经济负担。鉴于上述问题,本文合成了一种纳米银抗菌敷料,以控制溃疡表面的细菌感染,促进伤口愈合。本文描述了纳米银抗菌敷料的制备过程和形态特征。选择了 100 名患者,将其分为两组进行对比实验。常规组使用常规凡士林敷料,对照组使用纳米银抗菌敷料。分别分析溃疡表面愈合时间、换药次数和感染控制情况,并使用 SPSS19.0 进行统计分析。实验结果如下。使用纳米银抗菌敷料能显著降低糖尿病足患者的感染发生率,有助于减少换药次数,缩短溃疡愈合时间,加快周转速度。有助于缩短糖尿病足的病程,建议推广其临床应用。

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