Department of Vascular Surgery, The Second People's Hospital of Yunnan Province, Kunming City, Yunnan Province, 650021 China.
Department of Cardiovascul, People's Hospital of Xinjiang Uygur Autonomous Region, wulumuqi, Xinjiang, 830000, China.
Complement Ther Med. 2020 Nov;54:102579. doi: 10.1016/j.ctim.2020.102579. Epub 2020 Sep 22.
Although many studies have attempted to unravel the relationship between vitamin D deficiency and the incidence of VTE, the results remained inconsistent. To address this discrepancy, we performed a systematic review and meta-analysis to precisely disentangle the relationship between serum vitamin D levels and VTE risk.
The Web of Science, Scopus, PubMed/Medline, Embase, and Google Scholar databases were searched for all available observational studies that reported the risk of venous thromboembolism (VTE) based on serum vitamin D levels categories. The search was performed up to March 2020.
Seven studies were included. The overall analysis showed a significantly increased risk of VTE in subjects with low levels of serum vitamin D compared with those with normal vitamin D levels (RR = 1.34; 95% CI: 1.07-1.69; P = 0.011). In a sensitivity analysis, we did not observe a significant effect of any individual study on the combined effect sizes. Nevertheless, significant heterogeneity was present among the studies (Cochrane Q test, p = 0.018, I = 61%). In the stratified analysis, low vitamin D levels were positively associated with an increased risk of VTE in prospective population-based studies (RR = 1.31; 95% CI: 1.06-1.61; P = 0.010) and in subjects below 60 years old (RR = 1.28; 95% CI: 1.07-1.54; P = 0.060).
our systematic review and meta-analysis showed that a low serum vitamin D level was indeed associated with an increased risk of VTE.
尽管许多研究试图阐明维生素 D 缺乏与 VTE 发生率之间的关系，但结果仍不一致。为了解决这一差异，我们进行了系统评价和荟萃分析，以准确揭示血清维生素 D 水平与 VTE 风险之间的关系。
我们在 Web of Science、Scopus、PubMed/Medline、Embase 和 Google Scholar 数据库中搜索了所有基于血清维生素 D 水平类别报告静脉血栓栓塞 (VTE) 风险的观察性研究。搜索截至 2020 年 3 月。
纳入了 7 项研究。总体分析显示，与维生素 D 水平正常的受试者相比，血清维生素 D 水平低的受试者 VTE 风险显著增加（RR=1.34；95%CI：1.07-1.69；P=0.011）。在敏感性分析中，我们没有观察到任何一项研究对合并效应大小有显著影响。然而，研究之间存在显著的异质性（Cochrane Q 检验，p=0.018，I=61%）。在分层分析中，低维生素 D 水平与前瞻性基于人群的研究中 VTE 风险增加呈正相关（RR=1.31；95%CI：1.06-1.61；P=0.010），并且与 60 岁以下的受试者呈正相关（RR=1.28；95%CI：1.07-1.54；P=0.060）。
我们的系统评价和荟萃分析表明，低血清维生素 D 水平确实与 VTE 风险增加相关。
