Department of Medical Imaging, The Central People's Hospital of Huizhou, No. 41, Eling Road North, Huicheng District, Huizhou, 516001, Guangdong Province, China.
Department of Urology, The Central People's Hospital of Huizhou, No. 41, Eling Road North, Huicheng District, Huizhou, Guangdong Province, China.
Sci Rep. 2020 Nov 12;10(1):19649. doi: 10.1038/s41598-020-76776-x.
We examined characteristics of chest CT across different time periods for patients with COVID-19 pneumonia in Huizhou, China. This study included 56 COVID-19 patients with abnormal CT acquired between January 22 and March 3, 2020. The 141 scans of 56 patients were classified into four groups (Groups 1-4) based on dates on which scans were obtained at the 1st, 2nd, 3rd week or longer than three weeks after illness onset. Forty-five patients with follow-up scans were categorized into four groups (Groups A-D) according to extent that lesions reduced (≥ 75%, 50-75%, 25-50% and < 25%). Ground-glass opacities (GGO) was prevalent in Groups 1-4 (58.1-82.6%), while percentages of consolidation ranged between 9.7% in Group 4 and 26.2% in Group 2. The highest frequency of fibrous stripes occurred in Group 3 (46.7%). Total CT scores were on average higher in Groups 2-3. Among 45 follow-up patients, 11 (24.4%) of them recovered with lesions reducing ≥ 75%, with the lowest median age and total CT scores on admission. There are temporal patterns of lung abnormalities in COVID-19 patients, with higher extent of lesion involvement occurring in the 2nd and 3rd week. Persisting lung changes indicate some patients may need isolation after discharge from hospital.
我们研究了中国惠州 COVID-19 肺炎患者在不同时期的胸部 CT 特征。这项研究包括了 56 名在 2020 年 1 月 22 日至 3 月 3 日期间获得异常 CT 的 COVID-19 患者。将 56 名患者的 141 次扫描分为四组（第 1 组、第 2 组、第 3 组和 3 周以上组），依据的是扫描获取日期与发病后的第 1、2、3 周或超过 3 周。根据病变缩小程度（≥75%、50%-75%、25%-50%和＜25%），对 45 名有随访扫描的患者进行了分类（A-D 组）。第 1 组至第 4 组（58.1%-82.6%）多见磨玻璃影（GGO），而实变百分比在第 4 组（9.7%）和第 2 组（26.2%）之间。第 3 组纤维条纹的发生率最高（46.7%）。第 2 组和第 3 组的 CT 总评分平均较高。在 45 名随访患者中，有 11 名（24.4%）患者的病变缩小程度≥75%，入院时的中位年龄和 CT 总评分最低。COVID-19 患者的肺部异常存在时间模式，第 2 周和第 3 周病变累及程度较高。持续的肺部变化表明一些患者出院后可能需要隔离。
