Department of Biochemistry, National Defense Medical College, Tokorozawa, Saitama, Japan.
Curr Pharm Des. 2021;27(5):695-702. doi: 10.2174/1381612826666201113095938.
In 2007, Ohsawa and colleagues reported that molecular hydrogen (H) gas significantly reduced the infarct volume size in a rat model of cerebral infarction, which was, at least, partially due to scavenging hydroxyl radicals. Since then, multiple studies have shown that H has not only anti-oxidative but also anti-inflammatory and anti-apoptotic properties, which has ignited interest in the clinical use of H in diverse diseases. A growing body of studies has indicated that H affects both mental and physical conditions. Mental disorders are characterized by disordered mood, thoughts, and behaviors that affect the ability to function in daily life. However, there is no sure way to prevent mental disorders. Although antidepressant and antianxiety drugs relieve symptoms of depression and anxiety, they have efficacy limitations and are accompanied by a wide range of side effects. While mental disorders are generally thought to be caused by a variety of genetic and/or environmental factors, recent progress has shown that these disorders are strongly associated with increased oxidative and inflammatory stress. Thus, H has received much attention as a novel therapy for the prevention and treatment of mental disorders. This review summarizes the recent progress in the use of H for the treatment of mental disorders and other related diseases. We also discuss the potential mechanisms of the biomedical effects of H and conclude that H could offer relief to people suffering from mental disorders.
2007 年，大泽和他的同事们报告称，氢气（H）气体显著减少了脑梗死大鼠模型中的梗死体积大小，这至少部分是由于清除了羟自由基。从那时起，多项研究表明，H 不仅具有抗氧化作用，而且具有抗炎和抗凋亡作用，这激发了人们对 H 在多种疾病中的临床应用的兴趣。越来越多的研究表明，H 影响精神和身体状况。精神障碍的特征是情绪、思维和行为紊乱，影响日常生活的功能。然而，目前还没有预防精神障碍的确定方法。虽然抗抑郁药和抗焦虑药可以缓解抑郁和焦虑的症状，但它们的疗效有限，并且伴有广泛的副作用。虽然精神障碍通常被认为是由多种遗传和/或环境因素引起的，但最近的进展表明，这些障碍与氧化和炎症应激的增加密切相关。因此，H 作为预防和治疗精神障碍的一种新疗法受到了广泛关注。本综述总结了 H 在治疗精神障碍和其他相关疾病方面的最新进展。我们还讨论了 H 的生物医学作用的潜在机制，并得出结论，H 可以为患有精神障碍的人提供缓解。
