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前额叶-杏仁核-海马体网络中的神经炎症与适应不良的回避行为有关。

Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour.

作者信息

Antunes Geiza Fernanda, Gouveia Flavia Venetucci, Kuroki Mayra Akemi, Oliveira Martins Daniel, Pagano Rosana de Lima, Pinheiro Campos Ana Carolina, Martinez Raquel Chacon Ruiz

机构信息

Division of Neuroscience, Hospital Sirio-Libanes, Sao Paulo, Brazil.

Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.

出版信息

Heliyon. 2024 Apr 26;10(9):e30427. doi: 10.1016/j.heliyon.2024.e30427. eCollection 2024 May 15.

DOI:10.1016/j.heliyon.2024.e30427
PMID:38694029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11061725/
Abstract

Maladaptive avoidance behaviour is often observed in patients suffering from anxiety and trauma- and stressor-related disorders. The prefrontal-amygdala-hippocampus network is implicated in learning and memory consolidation. Neuroinflammation in this circuitry alters network dynamics, resulting in maladaptive avoidance behaviour. The two-way active avoidance test is a well-established translational model for assessing avoidance responses to stressful situations. While some animals learn the task and show adaptive avoidance (AA), others show strong fear responses to the test environment and maladaptive avoidance (MA). Here, we investigated if a distinct neuroinflammation pattern in the prefrontal-amygdala-hippocampus network underlies the behavioural difference observed in these animals. Wistar rats were tested 8 times and categorized as AA or MA based on behaviour. Brain recovery followed for the analysis of neuroinflammatory markers in this network. AA and MA presented distinct patterns of neuroinflammation, with MA showing increased astrocyte, EAAT-2, IL-1β, IL-17 and TNF-ɑ in the amygdala. This neuroinflammatory pattern may underlie these animals' fear response and maladaptive avoidance. Further studies are warranted to determine the specific contributions of each inflammatory factor, as well as the possibility of treating maladaptive avoidance behaviour in patients with psychiatric disorders with anti-inflammatory drugs targeting the amygdala.

摘要

适应不良的回避行为常出现在患有焦虑症以及创伤和应激源相关障碍的患者中。前额叶-杏仁核-海马体网络与学习和记忆巩固有关。该神经回路中的神经炎症会改变网络动态，导致适应不良的回避行为。双向主动回避测试是一种成熟的转化模型，用于评估对压力情境的回避反应。虽然一些动物学会了该任务并表现出适应性回避（AA），但另一些动物对测试环境表现出强烈的恐惧反应和适应不良的回避（MA）。在此，我们研究了前额叶-杏仁核-海马体网络中独特的神经炎症模式是否是这些动物行为差异的基础。对Wistar大鼠进行8次测试，并根据行为将其分类为AA或MA。随后对大脑进行恢复，以分析该网络中的神经炎症标志物。AA和MA呈现出不同的神经炎症模式，MA组杏仁核中的星形胶质细胞、EAAT-2、IL-1β、IL-十七和TNF-α增加。这种神经炎症模式可能是这些动物恐惧反应和适应不良回避行为的基础。有必要进一步研究以确定每种炎症因子的具体作用，以及使用针对杏仁核的抗炎药物治疗精神疾病患者适应不良回避行为的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/1a6445a8351b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/adab6fe90187/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/09747aad63a7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/3713a33796f5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/1a6445a8351b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/adab6fe90187/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/09747aad63a7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/3713a33796f5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6862/11061725/1a6445a8351b/gr4.jpg

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本文引用的文献

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