Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.
Center on Quality of Health and Living (CQHL), Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9300, Free State, South Africa.
Curr Pharm Des. 2021;27(4):490-504. doi: 10.2174/1381612826666201113094303.
The increasing interests on the healing properties of medicinal plants have led to a paradigm shift from the use of synthetic drug to the search of natural medicines for the treatment and management of several diseases. Like other phenolics flavonoids have been continuously explored for their medicinal benefits, with their potent antioxidant activity being a major interest. Kolaviron (KVN) is a biflavonoid isolated from Garcinia kola Heckel, which has been reported for its potent antioxidant and anti-inflammatory properties. These properties have been explored in several disease models including reproductive toxicity, cardiotoxicity, diabetes mellitus, gastrotoxicity and hepatotoxicity.
The present study was aimed to review the reported medicinal properties of KVN in order to provide some guidelines and direction to researchers on KVN research.
A literature search was conducted with the aim of identifying peer-reviewed published data on KVN and their biological activities. Different academic and/or scientific search engines were utilized including but not limited to Google Scholar, PubMed, ScienceDirect and so on.
Among all the studied disease models obtained from the literatures, the effect of KVN on reproductive toxicity was the most studied as it represented 25% of all the studies, followed by neuroprotective, cardioprotective and hepatoprotective activities of Kolaviron. From our identified studies, KVN has been shown to have antidiabetic, cardioprotective, neuroprotective, hematoprotective, nephroprotective, gastroprotective, hepatoprotective activities. KVN also has effects on malaria and reproductive health, which can be explored for novel drug and nutraceutical developments for related ailments. Unfortunately, while toxicity data are lacking, most studies are limited to in vitro and/or in vivo models, which may impede translation in this area of research.
Based on data gathered from the literature search, it is evident that KVN possesses numerous health benefits, which can be attributed to its potent antioxidant and anti-inflammatory activities. However, more studies are required in this area of research to validate the medicinal value of kolaviron, which may positively influence the economic value of plant, Garcinia kola.
对药用植物治疗特性的兴趣日益浓厚，导致人们从使用合成药物转变为寻找天然药物来治疗和管理多种疾病。与其他酚类化合物一样，类黄酮因其药用功效而不断被探索，其强大的抗氧化活性是主要关注点。Kolaviron（KVN）是从 Garcinia kola Heckel 中分离出来的双黄酮，据报道具有强大的抗氧化和抗炎特性。这些特性已在几种疾病模型中得到探索，包括生殖毒性、心脏毒性、糖尿病、胃肠道毒性和肝毒性。
本研究旨在综述 KVN 的已报道药用特性，为 KVN 研究人员提供一些指导和方向。
进行了文献检索，旨在确定有关 KVN 及其生物学活性的同行评审已发表数据。利用了不同的学术和/或科学搜索引擎，包括但不限于 Google Scholar、PubMed、ScienceDirect 等。
在所获得的文献中，所有研究的疾病模型中，研究 KVN 对生殖毒性的影响最多，占所有研究的 25%，其次是 Kolaviron 的神经保护、心脏保护和肝脏保护作用。从我们确定的研究中可以看出，KVN 具有抗糖尿病、心脏保护、神经保护、血液保护、肾脏保护、胃肠道保护、肝脏保护作用。KVN 还对疟疾和生殖健康有影响，可以探索用于相关疾病的新药和营养保健品的开发。不幸的是，虽然缺乏毒性数据，但大多数研究仅限于体外和/或体内模型，这可能会阻碍该研究领域的转化。
根据文献检索收集的数据，很明显 KVN 具有多种健康益处，这可归因于其强大的抗氧化和抗炎活性。然而，需要在这一研究领域进行更多的研究，以验证 kolaviron 的药用价值，这可能会对植物 Garcinia kola 的经济价值产生积极影响。
