School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand.
Phytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai, Thailand.
J Cosmet Dermatol. 2021 Jul;20(7):2160-2167. doi: 10.1111/jocd.13843. Epub 2020 Nov 26.
Para rubber (Hevea brasiliensis (Willd. ex A. Juss.) Müll. Arg.)) is the important crop of the word. It has been vastly used in biomedical products. However, its pharmacologically application besides the latex is sparely to be explored especially the seed. Cellular biological activities of the standardized para rubber seed oil for hair loss treatment were therefore assessed.
Para rubber seed oil was prepared and standardized using GC/MS on the basis of its pharmacologically active fatty acids. The oil was safety assessed in human dermal papilla and DU-145 human prostate carcinoma. Cellular antioxidant activity was determined as well as proliferation stimulating efficacy and inhibitory effect against 5α-reductase.
Oleic acid, fatty acid of cutaneous benefits, was majorly detected in the oil and followed by linoleic, palmitic, and stearic acids. The standardized para rubber seed oil was proved to be safe on human follicle dermal papilla and DU-145 human prostate carcinoma at the concentration of 0.1-50 and 0.1-100 µg/mL, respectively. The standardized para rubber seed oil stimulated the cell proliferation and posed cellular antioxidant activity in human dermal papilla at a comparable potency to minoxidil, dutasteride and vitamin C at the same tested concentration. In addition, the standardized para rubber seed oil inhibited 5α-reductase as examined in DU-145 human prostate carcinoma, although at a lesser degree than the standards at the same tested concentration.
The standardized para rubber seed oil is evidenced as the safe and efficient bio-oil to be used for hair growth stimulating or reduce/suppress hair loss treatment.
巴拉圭橡胶（巴西橡胶树（Willd. ex A. Juss.）Müll. Arg.）是世界上重要的作物。它已广泛应用于生物医学产品。然而，除了乳胶之外，其药理学应用几乎没有被探索，尤其是种子。因此，评估了标准化巴拉圭橡胶籽油治疗脱发的细胞生物学活性。
根据其药理活性脂肪酸，用 GC/MS 制备和标准化巴拉圭橡胶籽油。在人真皮乳头和 DU-145 人前列腺癌细胞中评估油的安全性。还测定了细胞抗氧化活性以及对 5α-还原酶的增殖刺激作用和抑制作用。
油中主要检测到油酸，一种皮肤有益的脂肪酸，其次是亚油酸、棕榈酸和硬脂酸。标准化巴拉圭橡胶籽油在 0.1-50 和 0.1-100μg/mL 的浓度下分别被证明对人毛囊真皮乳头和 DU-145 人前列腺癌细胞是安全的。标准化巴拉圭橡胶籽油在相同的测试浓度下，刺激人真皮乳头细胞增殖并具有细胞抗氧化活性，与米诺地尔、度他雄胺和维生素 C 的效力相当。此外，标准化巴拉圭橡胶籽油在 DU-145 人前列腺癌细胞中抑制 5α-还原酶，但在相同测试浓度下的抑制程度低于标准品。
标准化巴拉圭橡胶籽油是一种安全有效的生物油，可用于刺激头发生长或减少/抑制脱发治疗。
