目前对人类巨核红细胞祖细胞及其命运决定因素的认识。
Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants.
作者信息
Kwon Nayoung, Thompson Evrett N, Mayday Madeline Y, Scanlon Vanessa, Lu Yi-Chien, Krause Diane S
机构信息
Department of Cell Biology.
Yale Stem Cell Center.
出版信息
Curr Opin Hematol. 2021 Jan;28(1):28-35. doi: 10.1097/MOH.0000000000000625.
Abstract
PURPOSE OF REVIEW
This review focuses on our current understanding of fate decisions in bipotent megakaryocyte-erythroid progenitors (MEPs). Although extensive research has been carried out over decades, our understanding of how MEP commit to the erythroid versus megakaryocyte fate remains unclear.
RECENT FINDINGS
We discuss the isolation of primary human MEP, and focus on gene expression patterns, epigenetics, transcription factors and extrinsic factors that have been implicated in MEP fate determination. We conclude with an overview of the open debates in the field of MEP biology.
SUMMARY
Understanding MEP fate is important because defects in megakaryocyte and erythrocyte development lead to disease states such as anaemia, thrombocytopenia and leukaemia. MEP also represent a model system for studying fundamental principles underlying cell fate decisions of bipotent and pluripotent progenitors, such that discoveries in MEP are broadly applicable to stem/progenitor cell biology.
摘要
综述目的
本综述聚焦于我们目前对双能巨核细胞 - 红系祖细胞（MEP）命运决定的理解。尽管数十年来已开展了广泛研究，但我们对MEP如何决定向红系或巨核细胞命运分化仍不清楚。
最新发现
我们讨论了原代人MEP的分离，并着重关注了与MEP命运决定相关的基因表达模式、表观遗传学、转录因子和外在因素。最后我们概述了MEP生物学领域存在的开放性争论。
总结
了解MEP命运很重要，因为巨核细胞和红细胞发育缺陷会导致诸如贫血、血小板减少症和白血病等疾病状态。MEP也是研究双能和多能祖细胞命运决定基本原理的模型系统，因此在MEP方面的发现广泛适用于干细胞/祖细胞生物学。
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