Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal.
ICVS/3B's, PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
BMC Pregnancy Childbirth. 2020 Nov 13;20(1):693. doi: 10.1186/s12884-020-03376-y.
Iodine deficiency is the most common cause of preventable brain harm and cognitive impairment in children. Portuguese women of childbearing age, pregnant women and their progeny were shown to have inadequate iodine intake. Consequently, the Portuguese Health Authorities have recommended a daily supplementation with 150-200 µg iodine in preconception, pregnancy, and lactation. The IodineMinho study intends to evaluate whether (i) this recommendation impacted on the prevalence of iodine deficiency in pregnant women from the Minho region of Portugal, (ii) the time of initiation of iodine supplementation (if any) influences the serum levels of thyroid hormones at several intervals during pregnancy and (iii) there are serum thyroid-hormone parameters in the 1st trimester of pregnancy that predict psychomotor development of the child at 18 months of age.
Most Portuguese women are followed throughout pregnancy in community Family Health Units, where family physicians may choose to follow the National recommendation or other, concerning iodine sufficiency. This study will recruit women (N = 304) who intend to become pregnant or are already pregnant from 10 representative Units. Physician's approach and prescriptions, sociodemographic, nutrition and clinical information will be obtained at baseline and throughout pregnancy. To evaluate endocrine function, blood and urine samples will be collected at recruitment, once in each trimester of pregnancy, at delivery and 3 months after delivery. Breastmilk samples will be collected for iodine and energy content analysis. Children will be evaluated for psychomotor development at 18 months. Maternal thyroid volume will be evaluated by ultrasound scan at baseline, in the 3rd trimester and at 3 months after delivery.
Iodine deficiency early during development precludes children from achieving full intellectual capabilities. This protocol describes a study that is innovative and unique in its detailed and comprehensive evaluation of maternal and child endocrine and psychomotor parameters. By evaluating the effectiveness of the iodine supplementation recommendation, it will contribute to the public health systems' efforts to provide excellence in maternal and infant care.
ClinicalTrials.gov, NCT04288531 . Registered 28 February 2020-Retrospectively registered.
碘缺乏是儿童脑损伤和认知障碍最常见的可预防原因。葡萄牙育龄妇女、孕妇及其后代的碘摄入量不足。因此，葡萄牙卫生当局建议在受孕前、怀孕和哺乳期每天补充 150-200μg 碘。碘米尼奥研究旨在评估以下内容：(i) 该建议是否影响葡萄牙米尼奥地区孕妇的碘缺乏症患病率；(ii) 碘补充剂的起始时间（如有）是否会影响妊娠期间不同时间点的甲状腺激素血清水平；(iii) 妊娠 1 期是否存在甲状腺激素参数，可以预测 18 个月时儿童的精神运动发育。
大多数葡萄牙妇女在社区家庭健康单位（家庭医生可以选择遵循国家建议或其他关于碘充足的建议）中接受整个孕期的随访。该研究将招募来自 10 个代表性单位的有生育意愿或已怀孕的女性（N=304）。在基线和整个孕期将收集医生的方法和处方、社会人口统计学、营养和临床信息。为了评估内分泌功能，将在招募时、妊娠每三个月、分娩时和分娩后 3 个月采集血样和尿样。将收集母乳样本进行碘和能量含量分析。将在 18 个月时评估儿童的精神运动发育情况。在基线、妊娠第 3 期和分娩后 3 个月，将通过超声扫描评估产妇甲状腺体积。
早期发育过程中的碘缺乏会使儿童无法充分发挥智力。本方案描述了一项具有创新性和独特性的研究，详细全面地评估了母婴内分泌和精神运动参数。通过评估碘补充建议的有效性，该研究将有助于公共卫生系统为母婴护理提供卓越服务的努力。
ClinicalTrials.gov，NCT04288531。注册日期：2020 年 2 月 28 日-回顾性注册。
