• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

重新聚焦于感染和免疫介导性疾病的人类微生物组研究:迈向新阶段。

Refocusing Human Microbiota Research in Infectious and Immune-mediated Diseases: Advancing to the Next Stage.

机构信息

Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

J Infect Dis. 2021 Jul 2;224(1):5-8. doi: 10.1093/infdis/jiaa706.

DOI:10.1093/infdis/jiaa706
PMID:33188418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8253126/
Abstract

Changes in the microbiota are associated with disease susceptibility, immune system development, and responses to treatment. Refocusing research to elucidate the causal links between the human microbiota and infectious and immune-mediated diseases will be critical to harnessing its power to prevent, diagnose, and treat such diseases.

摘要

微生物组的变化与疾病易感性、免疫系统发育以及对治疗的反应有关。重新聚焦研究,阐明人类微生物组与感染和免疫介导性疾病之间的因果关系,对于利用其预防、诊断和治疗此类疾病的力量至关重要。

相似文献

1
Refocusing Human Microbiota Research in Infectious and Immune-mediated Diseases: Advancing to the Next Stage.重新聚焦于感染和免疫介导性疾病的人类微生物组研究:迈向新阶段。
J Infect Dis. 2021 Jul 2;224(1):5-8. doi: 10.1093/infdis/jiaa706.
2
Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer.肠道微生物组与免疫系统在传染病、免疫病理学和癌症中的相互作用。
Front Immunol. 2018 Aug 15;9:1830. doi: 10.3389/fimmu.2018.01830. eCollection 2018.
3
Refocusing Human Microbiota Research in Infectious and Immune-mediated Diseases: Advancing to the Next Stage.重新聚焦人类微生物群在感染性和免疫介导疾病中的研究:迈向新阶段。
Pediatr Infect Dis J. 2021 Oct 1;40(10):916. doi: 10.1097/INF.0000000000003299.
4
Gut Microbiota and Immune Responses.肠道微生物群与免疫应答
Adv Exp Med Biol. 2020;1238:165-193. doi: 10.1007/978-981-15-2385-4_10.
5
Modern World Influences on the Microbiome and Their Consequences for Immune-Mediated Disease.现代世界对微生物组的影响及其对免疫介导疾病的影响
J Immunol. 2021 Oct 1;207(7):1695-1696. doi: 10.4049/jimmunol.2190016.
6
Understanding the influence of the microbiome on childhood infections.了解微生物组对儿童感染的影响。
Expert Rev Anti Infect Ther. 2024 Jul;22(7):529-545. doi: 10.1080/14787210.2024.2340664. Epub 2024 Apr 12.
7
The role of the microbiota in infectious diseases.微生物群在传染病中的作用。
Nat Microbiol. 2019 Jan;4(1):35-45. doi: 10.1038/s41564-018-0278-4. Epub 2018 Dec 13.
8
Reciprocity in microbiome and immune system interactions and its implications in disease and health.微生物组与免疫系统相互作用中的互惠关系及其对疾病和健康的影响。
Inflamm Allergy Drug Targets. 2014;13(2):94-104. doi: 10.2174/1871528113666140330201056.
9
Role of IL-15 in immune-mediated and infectious diseases.IL-15 在免疫介导和感染性疾病中的作用。
Cytokine Growth Factor Rev. 2011 Feb;22(1):19-33. doi: 10.1016/j.cytogfr.2010.09.003. Epub 2010 Nov 11.
10
Chains of evidence from correlations to causal molecules in microbiome-linked diseases.从相关性到微生物组关联疾病中的因果分子的证据链。
Nat Chem Biol. 2021 Oct;17(10):1046-1056. doi: 10.1038/s41589-021-00861-z. Epub 2021 Sep 22.

引用本文的文献

1
A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response.利迪尼唑与万古霉素治疗艰难梭菌感染的随机、双盲、3期安全性和有效性研究:微生物组和代谢组与反应相关性的临床结果
Clin Infect Dis. 2024 Jun 14;78(6):1462-1472. doi: 10.1093/cid/ciad792.
2
Microbial metabolites: cause or consequence in gastrointestinal disease?微生物代谢产物:在胃肠道疾病中是原因还是结果?
Am J Physiol Gastrointest Liver Physiol. 2022 Jun 1;322(6):G535-G552. doi: 10.1152/ajpgi.00008.2022. Epub 2022 Mar 10.
3
Significance of the Gut Microbiome for Viral Diarrheal and Extra-Intestinal Diseases.肠道微生物组对病毒性腹泻和肠道外疾病的意义。
Viruses. 2021 Aug 12;13(8):1601. doi: 10.3390/v13081601.
4
Host microbiota can facilitate pathogen infection.宿主微生物群可以促进病原体感染。
PLoS Pathog. 2021 May 13;17(5):e1009514. doi: 10.1371/journal.ppat.1009514. eCollection 2021 May.

本文引用的文献

1
The Impact of the Microbiome on Immunity to Vaccination in Humans.微生物组对人类疫苗接种免疫的影响。
Cell Host Microbe. 2020 Aug 12;28(2):169-179. doi: 10.1016/j.chom.2020.06.014.
2
Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza.2019 年冠状病毒病或 H1N1 流感患者肠道微生物组的改变。
Clin Infect Dis. 2020 Dec 17;71(10):2669-2678. doi: 10.1093/cid/ciaa709.
3
SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial.SER-109,一种用于减少艰难梭菌感染后复发的研究性微生物组药物:来自 2 期试验的经验教训。
Clin Infect Dis. 2021 Jun 15;72(12):2132-2140. doi: 10.1093/cid/ciaa387.
4
Microbial bile acid metabolites modulate gut RORγ regulatory T cell homeostasis.微生物胆汁酸代谢物调节肠道 RORγ 调节性 T 细胞稳态。
Nature. 2020 Jan;577(7790):410-415. doi: 10.1038/s41586-019-1865-0. Epub 2019 Dec 25.
5
Depletion of microbiome-derived molecules in the host using genetics.利用遗传学耗尽宿主来源的微生物组分子。
Science. 2019 Dec 13;366(6471). doi: 10.1126/science.aav1282.
6
The role of the changing human microbiome in the asthma pandemic.人类微生物组变化在哮喘流行中的作用。
J Allergy Clin Immunol. 2019 Dec;144(6):1457-1466. doi: 10.1016/j.jaci.2019.10.022.
7
Bile acid metabolites control T17 and T cell differentiation.胆汁酸代谢物控制 T17 和 T 细胞分化。
Nature. 2019 Dec;576(7785):143-148. doi: 10.1038/s41586-019-1785-z. Epub 2019 Nov 27.
8
Drug-Resistant Bacteremia Transmitted by Fecal Microbiota Transplant.耐药菌血症通过粪便微生物群移植传播。
N Engl J Med. 2019 Nov 21;381(21):2043-2050. doi: 10.1056/NEJMoa1910437. Epub 2019 Oct 30.
9
MAIT cells are imprinted by the microbiota in early life and promote tissue repair.MAIT 细胞在生命早期受到微生物群的印记,并促进组织修复。
Science. 2019 Oct 25;366(6464). doi: 10.1126/science.aax6624.
10
Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes.大规模人类微生物组分析揭示了数千个小型新基因。
Cell. 2019 Aug 22;178(5):1245-1259.e14. doi: 10.1016/j.cell.2019.07.016. Epub 2019 Aug 8.