Deng J S, Bair L W, Shen-Schwarz S, Ramsey-Goldman R, Medsger T
Department of Dermatology, Verterans Administration Medical Center, Pittsburgh, PA 15240.
Arthritis Rheum. 1987 Nov;30(11):1232-8. doi: 10.1002/art.1780301105.
The presence of anti-Ro (SS-A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti-Ro (SS-A) antibodies in an indirect immunofluorescence assay, Ro (SS-A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS-A) antigen, anti-Ro (SS-A) antibody, and heart block is discussed.
母体血清中抗Ro（SS-A）抗体的存在与先天性心脏传导阻滞有关。在间接免疫荧光试验中使用对抗Ro（SS-A）抗体具有特异性的人血清，发现Ro（SS-A）抗原存在于心肌细胞和心脏传导系统细胞的细胞核中。本文讨论了Ro（SS-A）抗原的定位、抗Ro（SS-A）抗体与心脏传导阻滞之间的可能关系。
