Harley J B, Kaine J L, Fox O F, Reichlin M, Gruber B
Arthritis Rheum. 1985 Dec;28(12):1321-5. doi: 10.1002/art.1780281202.
Congenital complete heart block is closely associated with the presence of anti-Ro (SS-A) autoantibodies. Quantitative solid-phase assays for Ro (SS-A) autoantigen and autoantibody have established the presence of Ro (SS-A) in cardiac tissues and have been used to evaluate an informative pedigree. The propositus we describe here had complete congenital heart block and showed anti-Ro (SS-A) binding of 13-fold less than his normal HLA-identical twin sister. Both had identical titers of antinuclear antibody. These data support the hypothesis that anti-Ro (SS-A) may be directly involved in the pathogenesis of congenital complete heart block.
先天性完全性心脏传导阻滞与抗Ro（SS-A）自身抗体的存在密切相关。针对Ro（SS-A）自身抗原和自身抗体的定量固相检测已证实心脏组织中存在Ro（SS-A），并已用于评估一个有参考价值的家系。我们在此描述的先证者患有先天性完全性心脏传导阻滞，其抗Ro（SS-A）结合力比他正常的 HLA 相同的双胞胎姐姐低 13 倍。两人的抗核抗体滴度相同。这些数据支持抗Ro（SS-A）可能直接参与先天性完全性心脏传导阻滞发病机制的假说。
