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香蕉中的阿拉伯半乳聚糖:化学特性与药物作用。

Arabinogalactan in banana: Chemical characterization and pharmaceutical effects.

机构信息

China Tobacco Guangdong Industrial Co., Ltd., Guangzhou 510385, China.

China Tobacco Guangdong Industrial Co., Ltd., Guangzhou 510385, China.

出版信息

Int J Biol Macromol. 2021 Jan 15;167:1059-1065. doi: 10.1016/j.ijbiomac.2020.11.060. Epub 2020 Nov 11.

DOI:10.1016/j.ijbiomac.2020.11.060
PMID:33188809
Abstract

It is generally recognized that banana has diverse health benefits. However, most of the molecules responsible for the health benefits remain unknown. In this work, an important polysaccharide was extracted from banana and purified. The molecular weight was determined to be 526.2 kDa. It was identified by chemical and spectroscopic methods as arabinogalactan with β-D-(1→6)-galactan as backbone. This arabinogalactan was comprised of three monosaccharides, including Ara, Gal and GlcA with a relatively molar ratio of 5.8: 5.9: 1.0. The side chains were identified to be α-L-Araf-(1→, β-D-GlcpA-(1→, α-L-Araf-(1→5)-α-L-Araf-(1→ and α-D-Galp-(1→3)-α-L-Araf-(1→. They were linked to β-D-(1→6)-galactan at O-3, respectively. The putative structure was drawn as below. This arabinogalactan could induce NO production. It could also inhibit ROS production with a dose-dependent behaviour.

摘要

人们普遍认为香蕉具有多种健康益处。然而,大多数对健康有益的分子仍然未知。在这项工作中,从香蕉中提取并纯化了一种重要的多糖。分子量确定为 526.2 kDa。通过化学和光谱方法将其鉴定为具有β-D-(1→6)-半乳糖作为主链的阿拉伯半乳聚糖。该阿拉伯半乳聚糖由三种单糖组成,包括 Ara、Gal 和 GlcA,摩尔比为 5.8:5.9:1.0。侧链被鉴定为α-L-Araf-(1→、β-D-GlcpA-(1→、α-L-Araf-(1→5)-α-L-Araf-(1→和α-D-Galp-(1→3)-α-L-Araf-(1→。它们分别通过 O-3 与β-D-(1→6)-半乳糖连接。推测的结构如下所示。这种阿拉伯半乳聚糖可以诱导 NO 的产生。它还可以通过剂量依赖性行为抑制 ROS 的产生。

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