Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Ibadan, Nigeria.
Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Ibadan, Nigeria.
Environ Toxicol Pharmacol. 2021 Feb;82:103547. doi: 10.1016/j.etap.2020.103547. Epub 2020 Nov 11.
DDVP is a commonly used pesticide in Nigeria and those involved with DDVP manufacturing, packaging or utilizing facilities seldom use PPE to limit pesticide exposure. The study aim was to determine the impact of chronic exposure to DDVP by monitoring hematological and biochemical changes in Wistar rats. Male rats (n = 60; 150-180 g) were exposed to graded DDVP concentrations (0%, 20 %, 40 %, 60 %, 80 % and 100 %) via inhalation route for 60 days. Body weights were initially measured and then at 20-day intervals. Blood samples were collected for hematology and serum biochemistry on day 61. Results showed significant (p < 0.05) polycythemia, neutrophilia, thrombocytosis, hepatic and renal derangement in rats exposed to DDVP. Also, albumin, AST, ALP, creatinine, blood urea nitrogen, bilirubin levels and dyslipidemia significantly increased. Cholinergic signs and stunted growth were observed in higher concentrations. Study emphasized hazards of DDVP mishandling and risks of non-compliance with PPE use by workers in-contact with DDVP, as well as misuse/abuse in animals.
敌敌畏是尼日利亚常用的一种农药，从事敌敌畏生产、包装或使用设施的人员很少使用个人防护设备来限制接触农药。本研究旨在通过监测 Wistar 大鼠的血液学和生物化学变化，确定慢性接触敌敌畏的影响。雄性大鼠（n=60；150-180g）通过吸入途径暴露于不同浓度的敌敌畏（0%、20%、40%、60%、80%和 100%）60 天。最初测量体重，然后每 20 天测量一次。在第 61 天收集血液样本进行血液学和血清生物化学分析。结果表明，暴露于敌敌畏的大鼠出现明显的（p<0.05）红细胞增多症、中性粒细胞增多症、血小板增多症、肝肾功能障碍，白蛋白、AST、ALP、肌酐、血尿素氮、胆红素水平和血脂异常也明显升高。在较高浓度下观察到胆碱能症状和生长迟缓。研究强调了敌敌畏处理不当以及接触敌敌畏的工人不遵守个人防护设备使用规定以及在动物中滥用/误用的危害。
