School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China.
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Sci Total Environ. 2021 Mar 10;759:143555. doi: 10.1016/j.scitotenv.2020.143555. Epub 2020 Nov 6.
Limited evidence is available on the associations of long-term exposure to various fine particulate matter (PM) constituents with sub-clinical outcomes of cardiovascular disease (CVD) in China.
We aimed to explore the associations of PM and its constituents with blood pressure (BP), fasting glucose, and cardiac electrophysiological (ECG) properties based on a national survey of 5852 Chinese adults, who participated in the Sub-Clinical Outcome of Polluted Air study, from July 2017 to March 2019.
Annual residential exposure to PM and its constituents of each subject was predicted by a satellite-based mode. We assessed the associations between five main constituents [organic matter (OM), black carbon (BC), sulfate (SO), nitrate (NO), ammonium (NH)] of PM and systolic BP (SBP), diastolic BP (DBP), fasting glucose, and ECG measurements (PR, QRS, QT, and QTc interval) using multivariable linear regression models.
Long-term PM exposure was significantly associated with increased levels of fasting glucose, DBP, and ECG measurements. An IQR increase in OM (8.2 μg/m) showed considerably stronger associations with an elevated fasting glucose of 0.39 mmol/L (95%CI confidence interval: 0.28, 0.49) compared with other PM constituents. Meanwhile, an IQR increase in NO, NH and OM had stronger associations with DBP and ECG parameters compared with BC and SO.
This nationwide multi-center study in China indicated that some constituents (i.e., OM, NO, and NH) might be mainly responsible for the association of PM with sub-clinical outcomes of CVD including BP, fasting glucose, and ECG measurements.
在中国，关于长期暴露于各种细颗粒物（PM）成分与心血管疾病（CVD）亚临床结果的关联，证据有限。
我们旨在根据中国 5852 名成年人参与的空气污染亚临床后果研究，探索 PM 及其成分与血压（BP）、空腹血糖和心脏电生理（ECG）特性之间的关联，这些成年人于 2017 年 7 月至 2019 年 3 月参加了该项研究。
采用基于卫星的模型预测每位研究对象的年度居住环境中 PM 及其成分的暴露量。我们使用多变量线性回归模型评估了 PM 的五种主要成分（有机物（OM）、黑碳（BC）、硫酸盐（SO）、硝酸盐（NO）和铵（NH））与收缩压（SBP）、舒张压（DBP）、空腹血糖和心电图测量值（PR、QRS、QT 和 QTc 间期）之间的关联。
长期 PM 暴露与空腹血糖、DBP 和心电图测量值的升高水平显著相关。与其他 PM 成分相比，OM（8.2μg/m）每增加一个 IQR，空腹血糖升高 0.39mmol/L（95%CI 置信区间：0.28，0.49）的关联要强得多。同时，与 BC 和 SO 相比，NO、NH 和 OM 的 IQR 增加与 DBP 和 ECG 参数的关联更强。
这项在中国开展的全国多中心研究表明，一些成分（即 OM、NO 和 NH）可能是 PM 与 CVD 亚临床结果（包括 BP、空腹血糖和 ECG 测量值）相关的主要原因。
