School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Food Chem. 2021 Aug 15;353:128534. doi: 10.1016/j.foodchem.2020.128534. Epub 2020 Nov 4.
Rutin is a polyphenol with excellent therapeutic potential and good safety profile, but the poor bioavailability restricts its application as a functional ingredient. However, this limitation may be mitigated by encapsulation. In this study, promising prospects of starch nanoparticles (SNPs) produced via ultra-sonication for rutin encapsulation was explored.The rutin encapsulated SNPs prepared from quinoa and maize starch (QR and MR) showed average particle sizes of 107 and 222 nm, encapsulation efficiency (EE) and loading efficiency (LE) values of 67.4 and 63.1%, 26.6 and 22.7%, zeta potential of - 18.0 and - 18.6 mv, respectively. Structural, physical and thermal properties were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Simulated in vitro digestion showed increased rutin bioavailability with significantly higher (p < 0.05) in vitro antioxidant activities in QR than MR. Overall, SNPs prepared using ultrasound have potential to encapsulate polyphenols for improved bioavailability.
芦丁是一种具有优异治疗潜力和良好安全性的多酚，但生物利用度低限制了其作为功能成分的应用。然而，通过包封可以减轻这种局限性。在这项研究中，通过超声处理制备的淀粉纳米粒（SNP）被探索用于芦丁包封，具有很大的应用前景。从藜麦和玉米淀粉（QR 和 MR）制备的包封芦丁的 SNP 的平均粒径为 107nm 和 222nm，包封效率（EE）和载药量（LE）分别为 67.4%和 63.1%、26.6%和 22.7%，zeta 电位分别为-18.0mv 和-18.6mv。结构、物理和热性能通过傅里叶变换红外（FTIR）光谱、X 射线衍射（XRD）、扫描电子显微镜（SEM）和差示扫描量热法（DSC）进行了表征。模拟体外消化显示，QR 中芦丁的生物利用度增加，体外抗氧化活性明显高于 MR（p<0.05）。总的来说，超声法制备的 SNP 具有包封多酚以提高生物利用度的潜力。
