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2
Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units.美国和加拿大儿科重症监护病房收治的儿童 2019 年冠状病毒病(COVID-19)感染的特征和结局。
JAMA Pediatr. 2020 Sep 1;174(9):868-873. doi: 10.1001/jamapediatrics.2020.1948.
3
Children with Covid-19 in Pediatric Emergency Departments in Italy.意大利儿科急诊科的新冠病毒病患儿
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Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study.中国深圳 391 例病例及其 1286 名密切接触者的 COVID-19 流行病学和传播:一项回顾性队列研究。
Lancet Infect Dis. 2020 Aug;20(8):911-919. doi: 10.1016/S1473-3099(20)30287-5. Epub 2020 Apr 27.
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Novel coronavirus disease (COVID-19) in children.儿童新型冠状病毒病(COVID-19)。
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土耳其的 COVID-19 疫情:一家三级医疗中心的经验。

COVID-19 in Turkey: A tertiary center experience.

机构信息

Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.

Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.

出版信息

Pediatr Int. 2021 Jul;63(7):797-805. doi: 10.1111/ped.14549. Epub 2021 Apr 11.

DOI:10.1111/ped.14549
PMID:33190342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7753277/
Abstract

BACKGROUND

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem. The disease caused by the SARS-CoV-2 virus has been named as coronavirus disease 19 (COVID-19).

METHODS

We report on the epidemiological and clinical features of 37 children diagnosed with COVID-19.

RESULTS

The median age was of the children was 10 years and 57.1% were male. In addition, 78.3% of the children had a history of contact with adult patients who had been diagnosed with COVID-19, and 27.0% had coexisting medical conditions. We found that 40.5% of our patients had mild infection, while 32.4% had moderate infection, and 27.1% had developed severe or critical illness. The most common abnormal laboratory findings in our patients were decreased lymphocytes (45.9%) and increased D-dimer values (43.2%), while abnormal radiological findings were detected in 56.7% of the children. In addition, 64.8% of the children had received azithromycin, 59.4% had received oseltamivir, and hydroxychloroquine was used in combination with azithromycin in 35.1% of the children. Non-invasive mechanical ventilation was required in 27.0% of the children.

CONCLUSIONS

Although COVID-19 infection is usually mild in children, severe illness can be seen in children with comorbidities, or even in children who were previously healthy.

摘要

背景

自 2019 年 12 月以来,严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)在我国和世界各地引发了严重疫情,成为全球健康问题。由 SARS-CoV-2 病毒引起的疾病被命名为 2019 年冠状病毒病(COVID-19)。

方法

我们报告了 37 例确诊为 COVID-19 的儿童的流行病学和临床特征。

结果

儿童的中位年龄为 10 岁,男性占 57.1%。此外,78.3%的儿童有与确诊 COVID-19 的成人患者接触史,27.0%有并存的医疗条件。我们发现,40.5%的患者感染较轻,32.4%为中度感染,27.1%发展为重症或危重症。我们患者最常见的异常实验室发现是淋巴细胞减少(45.9%)和 D-二聚体值升高(43.2%),而 56.7%的儿童出现异常影像学发现。此外,64.8%的儿童接受了阿奇霉素,59.4%接受了奥司他韦,35.1%的儿童联合使用了羟氯喹和阿奇霉素。27.0%的儿童需要无创机械通气。

结论

尽管 COVID-19 感染在儿童中通常较轻,但有合并症的儿童,甚至以前健康的儿童也可能出现重症疾病。