Department of Pediatric Infectious Diseases, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.
Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.
Pediatr Int. 2021 Jul;63(7):797-805. doi: 10.1111/ped.14549. Epub 2021 Apr 11.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a serious epidemic in our country and all over the world since December 2019 and has become a global health problem. The disease caused by the SARS-CoV-2 virus has been named as coronavirus disease 19 (COVID-19).
We report on the epidemiological and clinical features of 37 children diagnosed with COVID-19.
The median age was of the children was 10 years and 57.1% were male. In addition, 78.3% of the children had a history of contact with adult patients who had been diagnosed with COVID-19, and 27.0% had coexisting medical conditions. We found that 40.5% of our patients had mild infection, while 32.4% had moderate infection, and 27.1% had developed severe or critical illness. The most common abnormal laboratory findings in our patients were decreased lymphocytes (45.9%) and increased D-dimer values (43.2%), while abnormal radiological findings were detected in 56.7% of the children. In addition, 64.8% of the children had received azithromycin, 59.4% had received oseltamivir, and hydroxychloroquine was used in combination with azithromycin in 35.1% of the children. Non-invasive mechanical ventilation was required in 27.0% of the children.
Although COVID-19 infection is usually mild in children, severe illness can be seen in children with comorbidities, or even in children who were previously healthy.
自 2019 年 12 月以来,严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)在我国和世界各地引发了严重疫情,成为全球健康问题。由 SARS-CoV-2 病毒引起的疾病被命名为 2019 年冠状病毒病(COVID-19)。
我们报告了 37 例确诊为 COVID-19 的儿童的流行病学和临床特征。
儿童的中位年龄为 10 岁,男性占 57.1%。此外,78.3%的儿童有与确诊 COVID-19 的成人患者接触史,27.0%有并存的医疗条件。我们发现,40.5%的患者感染较轻,32.4%为中度感染,27.1%发展为重症或危重症。我们患者最常见的异常实验室发现是淋巴细胞减少(45.9%)和 D-二聚体值升高(43.2%),而 56.7%的儿童出现异常影像学发现。此外,64.8%的儿童接受了阿奇霉素,59.4%接受了奥司他韦,35.1%的儿童联合使用了羟氯喹和阿奇霉素。27.0%的儿童需要无创机械通气。
尽管 COVID-19 感染在儿童中通常较轻,但有合并症的儿童,甚至以前健康的儿童也可能出现重症疾病。