Department of Chemistry, University of Turin, Torino, Italy.
Laboratoire de Chimie Moléculaire - CNRS/Ecole Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France.
Sci Total Environ. 2021 Feb 10;755(Pt 2):143556. doi: 10.1016/j.scitotenv.2020.143556. Epub 2020 Nov 6.
Maprotiline was identified as a compound of potential interest further to a suspect screening test carried out for a list of more than 40,000 substances based on specific occurrence, hazard and risk indicators. Despite the high frequency of appearance of this drug in wastewater treatment stations, his environmental fate is still unknown. Herein, we investigated for the first time the maprotiline degradation pathways in river water spiked with the drug at a concentration close to those detected in natural waters. Preliminary photocatalytic experiments in ultrapure water produced 32 transformation products (TPs) resulted mainly from the multiple hydroxylation/oxidation in different positions of the drug molecule. From the river water experiments, 12 TPs were formed by photolysis matching with those observed in ultrapure water experiments, and 2 were also formed resulted from biotic degradation. Employing HPLC-HRMS, we were able to elucidate the chemical structures of TPs and assess the overall degradation mechanism. Preliminary bioassays suggested lower toxicity of TPs relatively to the parent compound.
在对基于特定出现、危害和风险指标的超过 40,000 种物质的清单进行可疑筛选测试后，发现马普替林是一种具有潜在应用前景的化合物。尽管这种药物在污水处理厂中频繁出现，但它的环境归宿仍然未知。在此，我们首次研究了在接近天然水中检测到的浓度下在河水中添加该药物时马普替林的降解途径。在超纯水中进行的初步光催化实验产生了 32 种转化产物（TPs），主要来源于药物分子不同位置的多次羟化/氧化。从河水实验中，通过光解形成了 12 种与超纯水中实验观察到的相同的 TPs，还有 2 种则是由生物降解产生的。通过 HPLC-HRMS，我们能够阐明 TPs 的化学结构，并评估整体降解机制。初步的生物测定表明 TPs 的毒性相对母体化合物较低。
