Department of Environmental Chemistry, Faculty of Chemistry and Technology, University of Split, R. Boškovića 35, 21000 Split, Croatia.
Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia.
Sensors (Basel). 2022 Nov 26;22(23):9201. doi: 10.3390/s22239201.
Potentiometry with membrane selective electrodes is preferable for measuring the various constituents of pharmaceuticals. In this work, carbon paste electrodes (CPE) were prepared, modified, and tested for the determination of maprotiline hydrochloride, which acts as an antidepressant. The proposed CPE was based on an ionic association complex of maprotiline-tetraphenylborate, 2-nitrophenyloctyl as a binder, and sodium tetraphenylborate as an ionic lipophilic additive. The optimized composition improved potentiometric properties up to theoretical Nernst response values of -59.5 ± 0.8 mV dec, in the concentration range of maprotiline from 1.6 × 10 to 1.0 × 10 mol L, and a detection limit of 1.1 × 10 mol L. The CPE provides excellent reversibility and reproducibility, exhibits a fast response time, and is applicable over a wide pH range. No significant effect was observed in several interfering species tested. The proposed electrode was used for the precise determination of maprotiline in pure solutions, urine samples, and a real sample-the drug Ludiomil.
电位法用膜选择性电极更适合测量各种药物成分。在这项工作中，制备、修饰并测试了碳糊电极（CPE），用于测定盐酸马普替林，它是一种抗抑郁药。所提出的 CPE 基于马普替林-四苯硼酸盐的离子缔合配合物，2-硝基辛基苯作为粘合剂，四苯硼酸钠作为离子亲脂性添加剂。优化后的组成使电势性能提高，达到了 -59.5±0.8 mV dec 的理论 Nernst 响应值，在马普替林浓度范围为 1.6×10 至 1.0×10 mol L，检测限为 1.1×10 mol L。CPE 具有优异的可逆性和重现性，响应时间快，适用于较宽的 pH 范围。在测试的几种干扰物质中，没有观察到明显的影响。该电极用于纯溶液、尿液样品和实际样品——药物 Ludiomil 中马普替林的精确定量。
