Omori Reo, Fujiwara Satoru, Ishiyama Hiroyuki, Kuroda Hirokazu, Kohara Nobuo
Department of Neurology, Kobe City Medical Center General Hospital, Japan.
Department of Infectious Diseases, Kobe City Medical Center General Hospital, Japan.
Intern Med. 2020;59(22):2935-2936. doi: 10.2169/internalmedicine.5076-20. Epub 2020 Nov 15.
Leuconostoc lactis, often found in fermented dairy products, although considered to have a low pathogenic potential, can cause life-threatening infections in immunocompromised hosts. We herein report a 62-year-old man with a history of alcoholic liver cirrhosis, hepatocellular carcinoma, and diabetes mellitus who developed a very rare case of bacterial meningitis caused by this organism. After we administered antibiotics including ampicillin, he recovered completely within two weeks. This gram-positive coccus (GPC) is sensitive to ampicillin but naturally resistant to vancomycin, while its susceptibility to ceftriaxone has not yet been established. In acute GPC meningitis in immunocompromised hosts, Leuconostoc lactis should therefore be considered as a possible pathogen.
乳酸明串珠菌常见于发酵乳制品中，尽管其致病潜力被认为较低，但仍可在免疫功能低下的宿主中引起危及生命的感染。我们在此报告一名62岁男性，有酒精性肝硬化、肝细胞癌和糖尿病病史，他发生了由该菌引起的极为罕见的细菌性脑膜炎病例。在我们给予包括氨苄西林在内的抗生素后，他在两周内完全康复。这种革兰氏阳性球菌（GPC）对氨苄西林敏感，但对万古霉素天然耐药，而其对头孢曲松的敏感性尚未确定。因此，在免疫功能低下宿主的急性GPC脑膜炎中，应考虑乳酸明串珠菌为可能的病原体。
