Department of Internal Medicine, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Department of Rehabilitation Medicine, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Top Spinal Cord Inj Rehabil. 2020 Summer;26(3):172-176. doi: 10.46292/sci2603-172.
Spinal cord injury (SCI) affects the gastrointestinal (GI) tract in several ways, most notably by causing impairment of colonic motility and sphincter dysfunction. Altered GI function in the setting of neurological injury-also known as "neurogenic bowel dysfunction" (NBD) -strongly impacts the quality of life (QOL) of individuals living with SCI. Characterizing the severity of NBD, its impact on an individual's QOL, and which interventions have been successful or ineffective is integral to the routine care of people living with SCI. Treatment of NBD is generally multimodal and includes attention to diet, pharmacologic and mechanical stimulation, and possibly surgery. This article discusses the pathophysiology of NBD and specific approaches to its management.
脊髓损伤 (SCI) 通过多种方式影响胃肠道 (GI) 道,最显著的是导致结肠运动障碍和括约肌功能障碍。神经损伤背景下的胃肠道功能改变,也被称为“神经源性肠道功能障碍” (NBD) - 强烈影响生活在 SCI 中的个体的生活质量 (QOL)。NBD 的严重程度、对个体 QOL 的影响以及哪些干预措施是成功的或无效的,这对于生活在 SCI 中的人的常规护理至关重要。NBD 的治疗通常是多模式的,包括对饮食、药物和机械刺激的关注,以及可能的手术。本文讨论了 NBD 的病理生理学以及其管理的具体方法。